ProtocolEngine.io

Supplement Tier List

Every supplement ranked by the strength of its research. Click any supplement for full details, studies, and dosage.

S

Foundational supplements backed by decades of research and consistent results across thousands of people. Well-understood, strong safety profiles.

B

Promising research with some positive human studies, but often small, short-term, or limited to specific groups. Worth considering, but set expectations accordingly.

C

Early-stage or mixed evidence. May have strong lab or animal data but limited human research, or results that conflict across studies. Approach with healthy skepticism.

No supplements in this tier yet

D

Not recommended. Human studies show no benefit, potential harm, or the risks outweigh any possible upside. Save your money.

How to read this: Supplements are ranked by the quality and quantity of available research. S tier means strong evidence from multiple large, well-designed human studies. The number next to each supplement is the count of tracked studies. Click any supplement for dosage, safety, and study details.