GABA

Also known as: gamma-aminobutyric acid, pharmaGABA

Confidence

research strength

BBuilding confidence7017 studies referenced

Latest evidence update: 2026-05-13

Strongest in Replication (79). Held back by Sample size (58).

Study quality (37%)

Study design (21%)

Risk of bias (16%)

Solid mix of RCTs with some methodological gaps.

Replication (26%)

Cross-study replication (21%)

Precision (5%)

Confirmed across many independent studies with significant findings.

Sample size (16%)

Thousands of participants across the literature.

Consistency (11%)

Mostly aligned, with some divergence.

Recency (10%)

Healthy mix of recent and established research.

Effect by outcome

how big the change is

No quantified outcomes yet. Once we have studies with measurable endpoints, you will see per-outcome magnitude here.

Directional evidence

Areas where research points to a consistent direction of effect. The strength of evidence is graded; the size of the effect is not quantified.

Sleep & recovery Stress management Mental health & wellbeing

Common dosage

100-750mg daily

Description

Primary inhibitory neurotransmitter. Supplemental GABA may promote relaxation and sleep, though debate exists about blood-brain barrier crossing. PharmaGABA (natural fermentation) may be more effective than synthetic.

Safety & interactions

Generally safe. May cause drowsiness. Start low (100mg). Avoid combining with sedatives or anti-anxiety medications.

Check interactions with other supplements→

Some links on this page may earn us a commission at no extra cost to you. This never influences our evidence grades or recommendations. Full disclosure

Order GABA

Recommended: 100-750mg daily

Questions about GABA

Who has been studied for GABA?

Who should avoid GABA based on the safety notes?

What dose did studies use for GABA, and when was it taken?

Referenced studies (17)

ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.