Epitalon

Also known as: epithalon, ala-glu-asp-gly, agedg

Confidence

research strength

DPreliminary141 studies referenced

Latest evidence update: 2002-09-01

Strongest in Consistency (35). Held back by Sample size (5).

Study quality (37%)

Study design (21%)

Risk of bias (16%)

Limited to weak study designs or thin reporting.

Replication (26%)

Cross-study replication (21%)

Precision (5%)

Few independent replications; results not yet robust.

Sample size (16%)

Small combined sample; treat as preliminary.

Consistency (11%)

Mixed direction across studies.

Recency (10%)

Mostly pre-2020 research; updates may be needed.

Effect by outcome

how big the change is

No quantified outcomes yet. Once we have studies with measurable endpoints, you will see per-outcome magnitude here.

Longevity & aging

Common dosage

Research protocols use injectable peptide; oral formulations have unproven bioavailability.

Description

Synthetic tetrapeptide derived from the pineal peptide epithalamin, developed in Russia by Khavinson and Anisimov. Animal studies report telomerase activation, reduced spontaneous tumor incidence in mice, and modest lifespan extension. Independent replication outside the original Russian groups is sparse; human controlled trials are essentially absent.

Safety & interactions

Limited safety data outside the originating research groups. Not regulated as a supplement in most markets. Telomerase activation carries theoretical cancer-risk concerns that have not been adequately studied in humans.

Check interactions with other supplements→

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Order Epitalon

Recommended: Research protocols use injectable peptide; oral formulations have unproven bioavailability.

Questions about Epitalon

Who should avoid Epitalon based on the safety notes?

What dose did studies use for Epitalon, and when was it taken?

What does the research actually show Epitalon does?

Referenced studies (1)

ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.