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Selenium

Also known as: selenium methionine, selenomethionine

AAdequate Evidence16 studies referenced

Common dosage

100-200mcg daily

Category

mineral

Description

Trace mineral essential for thyroid function, antioxidant defense (glutathione peroxidase), and immune health.

Safety & interactions

Don't exceed 400mcg/day — toxicity risk. Brazil nuts provide ~70mcg each.
Check all interactions →

Studies on Selenium (16)

1.

Effects of selenium supplementation on cancer incidence: a meta-analysis

Lee EH, et al. (2011) · Nutr Cancer · n=44,743

Meta-analysisPubMed
2.

Selenium and thyroid disease: from pathophysiology to treatment

Duntas LH, Benvenga S (2015) · Int J Endocrinol

ReviewPubMed
3.

Clinical efficacy of selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and meta-analysis.

Zhang H (2025) · Medicine

4.

Adding L-Carnitine and Selenium to Methimazole in Graves' Disease: A Prospective Randomized Trial on Thyroid Markers and Quality of Life.

Rossi M (2025) · Nutrients

5.

Exploring the Impact of Selenium Supplementation on Nutritional, Inflammatory, and Cardiac Function in Chronic Heart Failure Patients: A Novel Approach to Managing Deficiency.

Kou L (2025) · Cardiovascular toxicology

6.

Impact of nano-selenium supplementation add-on sertraline on depressive symptoms and oxidative stress in patients with major depressive disorder: a triple-blind randomized controlled trial.

Noormohammadi M (2026) · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · n=50

7.

A Multicountry Analysis of Maternal Selenium Status in Pregnancy and Lactation and Infant Birth Outcomes: Findings from the Women First Maternal Preconception Study.

Gilley SP (2026) · The Journal of nutrition

8.

Selenium supplementation in individuals with newly diagnosed Graves' hyperthyroidism: a double-blind, multi-centre RCT.

Cramon PK (2026) · European thyroid journal

9.

A meta-analysis to study the effects and relationships of various selenium sources and forms on production performance, antioxidant status and egg quality of laying hens.

Yano AA (2025) · Journal of the science of food and agriculture

10.

Effect of selenium supplementation on hemodialysis patients: a meta-analysis.

Cheng Q (2025) · International urology and nephrology

11.

Effects of Selenium Administration on Blood Lipids: A Systematic Review and Dose-Response Meta-Analysis of Experimental Human Studies.

Urbano T (2026) · Nutrition reviews

12.

Selenium exposure and risk of skin cancer: A systematic review and dose-response meta-analysis of epidemiologic evidence.

Filippini T (2025) · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

13.

Effect of selenium supplementation on inflammatory markers and joint symptoms in patients with rheumatoid arthritis: A meta-analysis and systematic review.

Long M (2025) · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

14.

Selenium-Enriched Yeast Supplementation and Its Influence on Nerve Function Parameters and Oxidative Stress Markers in Diabetic Peripheral Neuropathy: A Randomized Placebo-Controlled Study.

Ghazisoltani M (2025) · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition

15.

Selenium supplementation for management of gestational diabetes mellitus in pregnancy: a systematic review and meta-analysis of randomized controlled trials.

Sun J (2025) · BMC endocrine disorders

16.

Impact of Nano-Selenium supplementation on the JAK/STAT signaling pathway in major depressive disorder: a Triple-Blind, randomized controlled trial.

Noormohammadi M (2025) · BMC psychiatry

ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.