Also known as: methylcobalamin, cyanocobalamin, cobalamin
Latest evidence update: 2026-04-23
Strongest in Sample size (95). Held back by Recency (28).
Solid mix of RCTs with some methodological gaps.
Confirmed across many independent studies with significant findings.
Tens of thousands of participants pooled across studies.
Mixed direction across studies.
Mostly pre-2020 research; updates may be needed.
Vitamin B12 supplementation during pregnancy helps vegetarian mothers maintain adequate B12 levels and supports healthy brain development in their babies
Low vitamin B12 levels during pregnancy are linked to slower brain development in infants and other pregnancy complications
People with Alzheimer's disease tend to have lower vitamin B12 levels than healthy individuals, suggesting a possible connection between B12 and brain health in aging
Fortified salt containing vitamin B12 does not reliably improve B12 levels and related health measures
Recommended: 1000mcg daily
ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.