Also known as: tryptophan
Latest evidence update: 2025-11-28
Strongest in Consistency (74). Held back by Recency (10).
Solid mix of RCTs with some methodological gaps.
Good cross-study replication, some imprecision.
Small combined sample; treat as preliminary.
Mostly aligned, with some divergence.
Mostly pre-2020 research; updates may be needed.
No quantified outcomes for L-Tryptophanyet. Once the corpus has studies with measurable endpoints, you'll see per-outcome magnitude here.
Recommended: 500mg before bed
ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.
May help reduce depressive symptoms when used alongside antidepressant medications
May help reduce symptoms of bipolar mania when added to standard psychiatric treatment
Improves sleep quality and reduces nighttime awakenings when combined with melatonin and vitamin B6
May improve emotional processing and mood by reducing negative emotional bias in middle-aged women
Helps lower elevated uric acid levels when combined with glycine, particularly in people with mild hyperuricemia