Also known as: silymarin, Silybum marianum
Latest evidence update: 2026-01-05
Strongest in Sample size (78). Held back by Recency (36).
Solid mix of RCTs with some methodological gaps.
Confirmed across many independent studies with significant findings.
Tens of thousands of participants pooled across studies.
Studies agree on direction of effect.
Evidence base skews older; field may have moved on.
Effect-size tagged on 390 of 400 claims for this supplement. Our research updates daily; remaining claims are pending re-processing.
Areas where research points to a consistent direction of effect. The strength of evidence is graded; the size of the effect is not quantified.
Recommended: 200-400mg silymarin daily
ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.
Reduces liver enzyme levels and protects liver function in patients with liver injury and disease
Improves insulin resistance in people with type 2 diabetes and alcoholic cirrhosis
Reduces kidney damage and serum creatinine levels in patients with drug-induced kidney injury
Improves cholesterol and triglyceride levels when combined with other nutrients
Shows limited effectiveness for chronic hepatitis C virus infection and non-alcoholic fatty liver disease