⚠️

Not recommended

Human studies show no meaningful benefit, potential harm, or the risks outweigh any possible upside. Better alternatives exist.

Pterostilbene

Also known as: trans-pterostilbene, blueberry stilbene

Confidence

research strength

EInsufficient evidence421 studies referenced

Latest evidence update: 2005-05-04

Strongest in Study quality (71). Held back by Replication (18).

Study quality (37%)

Study design (21%)

Risk of bias (16%)

Solid mix of RCTs with some methodological gaps.

Replication (26%)

Cross-study replication (21%)

Precision (5%)

Few independent replications; results not yet robust.

Sample size (16%)

Small combined sample; treat as preliminary.

Consistency (11%)

Mixed direction across studies.

Recency (10%)

Mostly pre-2020 research; updates may be needed.

Effect by outcome

how big the change is

No quantified outcomes yet. Once we have studies with measurable endpoints, you will see per-outcome magnitude here.

Longevity & aging Metabolic health

Common dosage

50–250 mg daily (animal-extrapolated; human optimal dose unknown)

Description

Methylated analog of resveratrol found in blueberries with substantially better bioavailability and longer half-life. Animal studies show PPAR-alpha agonism, lipid-lowering, neuroprotection, and SIRT1-related effects. Human supplementation evidence is limited and mixed.

Safety & interactions

Generally well-tolerated in short studies. May raise LDL cholesterol at higher doses in some reports. Avoid combining with stilbene-active medications.

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Order Pterostilbene

Recommended: 50–250 mg daily (animal-extrapolated; human optimal dose unknown)

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Questions about Pterostilbene

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Referenced studies (1)

ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.