⚠️

Not recommended

Human studies show no meaningful benefit, potential harm, or the risks outweigh any possible upside. Better alternatives exist.

Pterostilbene

Also known as: trans-pterostilbene, blueberry stilbene

Confidence

research strength

EInsufficient evidence421 studies referenced

Latest evidence update: 2005-05-04

Strongest in Study quality (71). Held back by Replication (18).

Study quality (37%)

Study design (21%)

Risk of bias (16%)

Solid mix of RCTs with some methodological gaps.

Replication (26%)

Cross-study replication (21%)

Precision (5%)

Few independent replications; results not yet robust.

Sample size (16%)

Small combined sample; treat as preliminary.

Consistency (11%)

Mixed direction across studies.

Recency (10%)

Mostly pre-2020 research; updates may be needed.

Effect by outcome

how big the change is

No quantified outcomes yet. Once we have studies with measurable endpoints, you will see per-outcome magnitude here.

Longevity & aging Metabolic health

Common dosage

50–250 mg daily (animal-extrapolated; human optimal dose unknown)

Description

Methylated analog of resveratrol found in blueberries with substantially better bioavailability and longer half-life. Animal studies show PPAR-alpha agonism, lipid-lowering, neuroprotection, and SIRT1-related effects. Human supplementation evidence is limited and mixed.

Safety & interactions

Generally well-tolerated in short studies. May raise LDL cholesterol at higher doses in some reports. Avoid combining with stilbene-active medications.

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Order Pterostilbene

Recommended: 50–250 mg daily (animal-extrapolated; human optimal dose unknown)

Questions about Pterostilbene

Who has been studied for Pterostilbene?

Who should avoid Pterostilbene based on the safety notes?

What dose did studies use for Pterostilbene, and when was it taken?

Referenced studies (1)

ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.