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Berberine

Also known as: berberine HCl

AAdequate Evidence8 studies referenced

Common dosage

500mg 2-3x daily with meals

Category

herb

Description

Plant alkaloid with strong evidence for blood sugar management, comparable to metformin in some studies. Also supports gut microbiome diversity.

Safety & interactions

Take with meals. May cause GI discomfort initially. Interacts with many medications — consult doctor.
Check all interactions →

Protocols featuring Berberine

Gut Health ResetAAdequate Evidence
Metabolic Health OptimizerAAdequate Evidence

Studies on Berberine (8)

1.

Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins

Kong W, et al. (2004) · Nat Med · n=91

RCTPubMedDOI
2.

Efficacy of Berberine in Patients with Type 2 Diabetes Mellitus

Liang Y, et al. (2019) · Metabolism · n=2,569

Meta-analysisPubMedDOI
3.

Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes: A Randomized Clinical Trial.

Ji L (2025) · JAMA network open

PubMedDOI
4.

The efficacy and safety of berberine in combination with cinnamon supplementation in patients with type 2 diabetes: a randomized clinical trial.

Mansour A (2025) · European journal of nutrition

PubMedDOI
5.

The Influence of Berberine on Vascular Function Parameters, Among Them VEGF, in Individuals with MAFLD: A Double-Blind, Randomized, Placebo-Controlled Trial.

Koperska A (2025) · Nutrients

PubMedDOI
6.

Berberine and Adiposity in Diabetes-Free Individuals With Obesity and MASLD: A Randomized Clinical Trial.

Lei L (2026) · JAMA network open

PubMedDOI
7.

The effects of Gegen Qinlian decoction and its main constituents on glucolipid metabolic disorders in diabetes: an overview of systematic reviews and meta-analysis.

Xue C (2025) · Systematic reviews

PubMedDOI
8.

Gegen Qinlian decoction ameliorates insulin resistance in type 2 diabetes: A systematic review and meta-analysis of RCTs with mechanistic insights into SIRT1/AMPK pathway activation.

Liao Y (2026) · Journal of ethnopharmacology

PubMedDOI

Health domains

Metabolic healthGut health & microbiomeCardiovascular health

ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.