Also known as: berberine HCl
Latest evidence update: 2026-03-01
Strongest in Consistency (78). Held back by Recency (42).
Solid mix of RCTs with some methodological gaps.
Confirmed across many independent studies with significant findings.
Tens of thousands of participants pooled across studies.
Studies agree on direction of effect.
Evidence base skews older; field may have moved on.
May help improve blood sugar control and support diabetes management
May help improve cholesterol levels by reducing triglycerides and total cholesterol while increasing good cholesterol
May support heart and blood vessel health through antioxidant and protective effects
May help reduce inflammation in fatty liver disease
Recommended: 500mg 2-3x daily with meals
ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.
Appears to be safe when used alone or combined with cinnamon in people with type 2 diabetes