Also known as: AKG, calcium alpha-ketoglutarate, CaAKG
Latest evidence update: 2026-12-31
Strongest in Study quality (57). Held back by Replication (31).
Solid mix of RCTs with some methodological gaps.
Few independent replications; results not yet robust.
Hundreds of participants; meaningful but not large.
Mixed direction across studies.
Evidence base skews older; field may have moved on.
No per-outcome numbers yet for this one. Each finding's direction and strength is shown in the research below.
Does not improve muscle endurance or performance during resistance training in trained individuals
May actually reduce the number of repetitions completed during resistance exercises compared to placebo
Does not affect blood pressure response during or after resistance training
Recommended: 1000mg daily (as calcium AKG)
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