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Not recommended

Human studies show no meaningful benefit, potential harm, or the risks outweigh any possible upside. Better alternatives exist.

Alpha-Ketoglutarate

Also known as: AKG, calcium alpha-ketoglutarate, CaAKG

EInsufficient4518 studies referenced

Latest evidence update: 2026-12-31

Longevity & aging

Common dosage

1000mg daily (as calcium AKG)

Description

Key metabolite in the Krebs cycle. Supplementation in mice extended lifespan by ~12% and compressed morbidity. May work through epigenetic mechanisms and TET enzyme activation.

Safety & interactions

Naturally occurring metabolite. Generally well-tolerated. Human aging trials are ongoing but results not yet published.

Check interactions with other supplements→

What the research shows

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Does not improve muscle endurance or performance during resistance training in trained individuals

strong evidence1 study:Journal of strength and conditioning research (2011)

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May actually reduce the number of repetitions completed during resistance exercises compared to placebo

moderate evidence1 study:Journal of strength and conditioning research (2011)

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Does not affect blood pressure response during or after resistance training

strong evidence1 study:Journal of strength and conditioning research (2011)

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Order Alpha-Ketoglutarate

Recommended: 1000mg daily (as calcium AKG)

Questions about Alpha-Ketoglutarate

Who has been studied for Alpha-Ketoglutarate?

Who should avoid Alpha-Ketoglutarate based on the safety notes?

What dose did studies use for Alpha-Ketoglutarate, and when was it taken?

Referenced studies (18)

ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.