Also known as: 5-hydroxytryptophan, griffonia simplicifolia
Latest evidence update: 2026-05-01
Strongest in Consistency (95). Held back by Sample size (18).
Solid mix of RCTs with some methodological gaps.
Some independent replication, statistical precision uneven.
Small combined sample; treat as preliminary.
Studies agree on direction of effect.
Evidence base skews older; field may have moved on.
No quantified outcomes for 5-HTPyet. Once the corpus has studies with measurable endpoints, you'll see per-outcome magnitude here.
Recommended: 50-100mg daily
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May help reduce depression and improve mood in older adults
May improve sleep quality in people with poor sleep patterns
May help reduce body weight and appetite in overweight individuals
May improve motor function and reduce REM sleep behavior symptoms in Parkinson's disease patients
May improve cognitive function in older adults