Also known as: 2-aminoethanesulfonic acid
Latest evidence update: 2026-04-01
Strongest in Replication (82). Held back by Recency (38).
Solid mix of RCTs with some methodological gaps.
Confirmed across many independent studies with significant findings.
Tens of thousands of participants pooled across studies.
Mostly aligned, with some divergence.
Evidence base skews older; field may have moved on.
Effect-size tagged on 386 of 400 claims for this supplement. Our research updates daily; remaining claims are pending re-processing.
Areas where research points to a consistent direction of effect. The strength of evidence is graded; the size of the effect is not quantified.
Recommended: 1-3g daily
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Improves exercise performance, particularly in aerobic endurance, strength, power, and agility tasks
Helps the body cool down in hot environments by increasing sweating and lowering core temperature
When combined with caffeine, significantly enhances endurance performance and jumping power, particularly in challenging oxygen conditions
May support cognitive function when combined with medical treatments, though effects are unclear when used alone
May improve metabolic health markers including blood lipids, blood sugar, and insulin sensitivity in people with excess weight