Also known as: N-acetylcysteine, NAC
Latest evidence update: 2026-05-27
Strongest in Sample size (95). Held back by Recency (36).
Solid mix of RCTs with some methodological gaps.
Confirmed across many independent studies with significant findings.
Tens of thousands of participants pooled across studies.
Mostly aligned, with some divergence.
Evidence base skews older; field may have moved on.
Recommended: 600-1200mg daily
ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.
Reduces kidney damage from contrast dye exposure and certain medications, particularly when combined with hydration or other protective measures
Improves outcomes in liver transplants by reducing complications and graft failure rates
Enhances male fertility by increasing sperm concentration and improving sperm shape
Reduces depression symptoms, particularly when added to antipsychotic or bipolar medications
Boosts the body's natural antioxidant defenses by increasing glutathione levels