NAC (N-Acetyl Cysteine)

N-Acetylcysteine in Psychiatry: Current Therapeutic Evidence and Potential Mechanisms of Action

Deepmala, et al. (2015) · J Clin Psychiatry

The role of N-acetylcysteine in the treatment of substance use disorders

Nocito Echevarria MA, et al. (2017) · Clin Psychopharmacol Neurosci

Intraoperative neurophysiological monitoring versus no monitoring in intradural extramedullary tumor surgery: a systematic review and meta-analysis of early postoperative neurological outcomes.

Correa EM (2026) · Neurosurgical review · n=602

The impact of body mass index on the treatment response to neoadjuvant chemotherapy in patients with breast cancer: A systematic review and meta-analysis.

Zhang L (2026) · Tumori

Preventing Contrast-Induced Acute Kidney Injury in Egyptian Patients Undergoing Coronary Angiography: A Randomized Controlled Trial.

Sabry S (2026) · Clinical drug investigation

Administration of N-acetylcysteine influence the expression of apoptotic genes in the granulosa cells of infertile women diagnosed with endometriosis.

Heshmati ZS (2026) · Scientific reports

Predictors of postoperative complications following staged nipple-sparing mastectomy: A systematic review & meta-analysis.

Darras O (2026) · Journal of plastic, reconstructive & aesthetic surgery : JPRAS

Identifying a conserved transcriptional signature of drought and salt stress in Arabidopsis thaliana through meta-analysis, consensus network analysis, and deep learning.

Hakkak MM (2026) · Genetica

N-Acetylcysteine is associated with changes in functional connectivity in patients with Parkinson's disease.

Monti DA (2026) · Parkinsonism & related disorders

Frontal white matter hyperintensity burden predicts cognitive response to N-acetylcysteine and exercise in vascular mild cognitive impairment.

Mah E (2026) · Neurobiology of aging

Glycaemic, appetite and circadian benefits of a dairy-enriched diet with high-protein breakfast and early daytime-restricted carbohydrate intake in type 2 diabetes: a randomised crossover trial.

Tsameret S (2026) · Diabetologia

N-acetylcysteine reduces incidence and duration of linezolid-associated thrombocytopenia in critically ill patients: A randomized controlled trial.

Abdeltawab M (2026) · Environmental toxicology and pharmacology

Divergent neural mechanisms of reward processing and cognitive control in non-substance and substance addiction: A meta-analytic perspective.

Li Q (2026) · NeuroImage

Ultrasound for predicting pathological response to neoadjuvant chemotherapy in patients with breast cancer: a systematic review and meta-analysis.

Shi QF (2026) · BMC cancer

Fluoxetine versus N-acetylcysteine in reducing craving in Indian men with alcohol dependence syndrome: a randomised controlled trial.

Shruthi T (2025) · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan

Single-port robotic nipple-sparing mastectomy: a systematic review and single-arm meta-analysis of safety and process outcomes.

Ouyang R (2025) · Journal of robotic surgery

Topical application of the antimuscarinic pirenzepine increased lower limb nerve fibre density in a phase 2a study in type 2 patients with diabetes with peripheral neuropathy.

Sivadasan A (2026) · EBioMedicine

Diagnostic accuracy of artificial intelligence-assisted 18f-fdg pet/ct for predicting pathological complete response to neoadjuvant chemotherapy in breast cancer: a systematic review and meta-analysis.

Xie C (2026) · Annals of nuclear medicine · n=3,038

Nivolumab in combination with ipilimumab versus capecitabine as post-operative treatment for triple negative breast cancer patients with residual disease after neoadjuvant chemotherapy: a multicentre, randomized, open-label phase II trial - BREASTIMMUNE-03.

Trédan O (2026) · Breast (Edinburgh, Scotland)

Immunohistochemical Changes After Neoadjuvant Chemotherapy and Their Impact on Breast Cancer Survival: A Systematic Review and Meta-analysis.

Antonini M (2026) · Clinical breast cancer · n=5,891

Prefrontal-bed nucleus of the stria terminalis physiological and neuropsychological biomarkers predict therapeutic outcomes in depression.

Wang L (2025) · Nature communications

Can radiomics from dynamic contrast-enhanced MRI effectively predict response to neoadjuvant chemotherapy in breast cancer?: A meta-analysis.

Ye T (2026) · Clinical radiology

A Systematic Review and Meta-analysis Comparing Inferior Pedicle and Superomedial Pedicle Techniques in Reduction Mammaplasty for Gigantomastia: Postoperative Complications, Aesthetic Outcomes and Quality of Life.

Johow M (2026) · Aesthetic plastic surgery

Post hoc subgroup analysis of neoadjuvant gemcitabine plus S1 vs gemcitabine plus nab paclitaxel in elderly resectable/borderline resectable pancreatic adenocarcinoma.

Yamada D (2025) · Scientific reports

Circulating miR-19, miR-27a, and miR-200c as novel biomarkers for resistance to neoadjuvant chemotherapy in gastric cancer patients: a pilot study.

Baušys B (2025) · Scientific reports · n=39

Efficacy of N-Acetylcysteine in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis: a systematic review and meta-analysis.

Hormati A (2025) · BMC gastroenterology

Therapeutic deep brain stimulation targeting BNST-NAc circuit driven large-scale brain networks in treatment-resistant depression.

Ye K (2025) · Translational psychiatry

High Loss of Adipose Tissue During Neoadjuvant Chemotherapy Predicts Poor Prognosis in Patients With Gastric Cancer.

He C (2025) · Journal of cachexia, sarcopenia and muscle

Pharmacokinetics and bioequivalence of two N-acetylcysteine tablets in healthy Chinese volunteers under fasting and fed conditions.

Yin X (2026) · Clinical pharmacology in drug development

Correlation of plasma lipidomic profiles with cardiometabolic disease in transfusion-dependent thalassemia patients with six-month N-acetylcysteine intervention: A prospective cohort study.

Lei Y (2025) · Clinical biochemistry

Survival impact of residual disease and timing of surgery in the management of advanced-stage low grade serous ovarian cancer: A systematic review and meta-analysis.

Hotton J (2025) · Gynecologic oncology

The Effect of N-Acetylcysteine (NAC) on Neurometabolites and Cognitive Function in Adults With Alcohol Use Disorder: A Preliminary Randomized Controlled Trial.

Dunbar KY (2025) · Neuropsychopharmacology reports

MRI-based radiomics models for early predicting pathological response to neoadjuvant chemotherapy in triple-negative breast cancer: A systematic review and meta-analysis.

Zhang J (2025) · Journal of applied clinical medical physics

Indocyanine green-guided lymphadenectomy in gastric cancer after neoadjuvant chemotherapy: A systematic review and meta-analysis.

Fernandes MHF (2025) · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Genomic and transcriptomic analyses of residual invasive triple-negative breast cancer after neoadjuvant chemotherapy in the prospective MIRINAE trial (a randomized phase II trial of adjuvant atezolizumab plus capecitabine compared to capecitabine; KCSG-BR18-21).

Im SA (2025) · ESMO open

Artificial intelligence-assisted PET imaging for predicting neoadjuvant chemotherapy response in breast cancer: a systematic review and meta-analysis.

Chen Y (2026) · European journal of nuclear medicine and molecular imaging

Comparison of adjuvant and neoadjuvant therapies for muscle invasive bladder cancer: A network meta-analysis.

Petrelli F (2026) · Urologic oncology · n=5,026

Efficacy of N-acetylcysteine vs dexamethasone in preventing postembolization syndrome post-transarterial chemoembolization in hepatocellular carcinoma: A randomized controlled trial.

Koonsiripaiboon P (2025) · World journal of gastroenterology

Methods of topical fluoride application in the arrest of root carious lesions of adults and elderly patients: A systematic review with network meta-analysis.

Torres JM (2025) · Journal of dentistry

Targeted Nipple-Areola Complex (NAC) Reinnervation (TNR): A Systematic Review and Meta-Analysis.

Nguyen AT (2026) · Aesthetic plastic surgery

N-Acetylcysteine for the Treatment of Co-Occurring Posttraumatic Stress Disorder and Alcohol Use Disorder: A Double-Blind, Randomized Controlled Trial.

Back SE (2025) · The Journal of clinical psychiatry · n=182

CT staging performance in an international trial of neoadjuvant chemotherapy for locally advanced colon cancer.

Platt JR (2025) · The British journal of radiology

Oncological outcomes of sentinel lymph node biopsy alone in patients with residual nodal disease after neoadjuvant chemotherapy for breast cancer: a systematic review and meta-analysis.

Zaborowski AM (2025) · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Efficacy and safety of N-acetylcysteine vs. probiotics in in-vivo biofilm prevention on ureteral stents: a prospective randomized controlled pilot in vivo study.

Singh I (2026) · International urology and nephrology

Effects of high-protein nutritional supplementation on nutritional status, physical function, and quality of life in older gastric cancer patients receiving neoadjuvant chemotherapy: a randomized trial.

Doğan Akagündüz D (2025) · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Diazepam modulates hippocampal CA1 functional connectivity in people at clinical high-risk for psychosis.

Livingston NR (2025) · Psychological medicine

Ultrasound-based machine learning models for predicting response to neoadjuvant chemotherapy in breast cancer: A meta-analysis.

Valizadeh P (2025) · Clinical imaging

Assessing racial disparities in disease outcomes of patients with high-risk, triple-negative breast cancer and residual disease after neoadjuvant therapy: a post-hoc analysis of the ECOG-ACRIN 1131 clinical trial.

Lloyd K (2025) · Breast cancer research and treatment

Efficacy Of N-Acetyl-Cysteine as Adjuvant Therapy for Diabetic Foot Osteomyelitis: An Open-Label Randomized Controlled Trial.

Hooshmand Gharabagh L (2025) · Archives of Iranian medicine

Exploratory unsupervised machine learning of angiogenesis biomarkers in a phase II advanced cervical cancer trial of radiochemotherapy with or without neoadjuvant chemotherapy.

Arai RJ (2025) · Clinics (Sao Paulo, Brazil)

Effect of N-Acetylcysteine on mortality in COVID-19 patients: A systematic review and meta-analysis of randomized controlled trials.

Kow CS (2025) · Inflammopharmacology

Comparative effectiveness of colonic stenting alone and with neoadjuvant chemotherapy for patients with left-sided obstructive colon cancer: a meta-analysis.

Sun Q (2025) · International journal of surgery (London, England)

Emergency adjunctive therapy for organophosphate poisoning: A meta-analysis.

Wang L (2025) · International emergency nursing

Impact of Neoadjuvant Chemotherapy on Surgical Outcomes and Conversion to Node-Negativity in Invasive Lobular Breast Cancer: Analysis of Molecularly High-Risk Tumors by Histologic Subtype on the I-SPY2 Clinical Trial.

Mukhtar RA (2025) · Annals of surgical oncology

Executive Dysfunction and Disability in SPMS: Predictive Value of the Frontal Assessment Battery in the UCLH MS-STAT2 Cohort.

Wade C (2025) · European journal of neurology

Efficacy of neoadjuvant therapy in gallbladder cancer: a meta-analysis using reconstructed time-to-event data.

Loke S (2025) · Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

Utility of Tranexamic Acid in Reduction Mammaplasty: A Systematic Review and Meta-Analysis.

Fung E (2025) · Aesthetic plastic surgery

Global Synthesis of Fertilisation-Induced Changes in the Microbial Entombing Effect.

Fu H (2025) · Global change biology

Oncological Outcomes of Neoadjuvant Chemotherapy Versus Upfront Surgery in Locally Advanced Colon Cancer: A Systematic Review, Meta-Analysis, and Sequential Analysis.

Sassun R (2025) · Annals of surgical oncology

Prehabilitation during neoadjuvant chemotherapy results in an enhanced immune response in esophageal adenocarcinoma tumors: A randomized controlled trial.

Rayner CJ (2025) · Journal of sport and health science

Long-term efficacy of tafamidis in patients with transthyretin amyloid cardiomyopathy by National Amyloidosis Centre stage.

Damy T (2025) · European journal of heart failure

New Approach Combination-Dosed Therapy for Nonalcoholic Steatohepatitis Versus Vitamin E: A Randomized Controlled Trial.

Zakaria AY (2025) · Clinical therapeutics

The effect of postmastectomy radiotherapy after neoadjuvant chemotherapy in patients with breast cancer: a meta-analysis.

Zou A (2025) · Future oncology (London, England)

COVID-19 clinical outcomes and N-acetylcysteine (CoViNAC study): a GRADE compliant meta-analysis of randomized controlled trials with molecular docking and dynamics simulation studies with Mpro of SARS-CoV-2.

Varikasuvu SR (2025) · Cellular and molecular biology (Noisy-le-Grand, France) · n=1,125

Clinical Response to Resynchronization Therapy: Conduction System Pacing vs Biventricular Pacing: The CONSYST-CRT Trial.

Pujol-López M (2025) · JACC. Clinical electrophysiology

Efficacy of N-acetylcysteine and motivational enhancement therapy for nicotine addiction: A randomized clinical trial.

Nasrun MW (2025) · Narra J

Meta-analysis of the efficacy and safety of L-carnitine and N-acetylcysteine monotherapy for male idiopathic infertility.

Ma X (2025) · Revista internacional de andrologia

Radiomics-based machine learning in prediction of response to neoadjuvant chemotherapy in osteosarcoma: A systematic review and meta-analysis.

Salimi M (2025) · Clinical imaging

N-acetylcysteine for the Prevention of Cisplatin-Induced Hearing Loss: A Systematic Review and Meta-analysis.

Plane J (2025) · Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

Impact of postmastectomy radiotherapy on locoregional recurrence and survival in patients with ypN0 breast cancer after neoadjuvant chemotherapy: A comprehensive meta-analysis and systematic review.

Ding F (2025) · Journal of cancer research and therapeutics

Neoadjuvant chemotherapy for colon cancer: A systematic review and meta-analysis of randomized controlled trials.

Noronha MM (2025) · European journal of cancer (Oxford, England : 1990)

The use of indocyanine green and near-infrared fluorescence in the detection of metastatic lymph nodes during oesophageal and gastric cancer resection: a systematic review and meta-analysis.

Slim N (2025) · Surgical endoscopy

Neoadjuvant Chemotherapy With Gemcitabine and S-1 Versus Upfront Surgery for Resectable Pancreatic Cancer: Results of the Randomized Phase II/III Prep-02/JSAP05 Trial.

Unno M (2026) · Annals of surgery

Repurposing of high-dose N-acetylcysteine as anti-inflammatory, antioxidant and neuroprotective  agent  in moderate to severe traumatic brain injury patients: a randomized controlled trial.

Gouda AR (2025) · Inflammopharmacology

Neoadjuvant FOLF(IRIN)OX Chemotherapy for Resectable Pancreatic Adenocarcinoma: A Multicenter Randomized Noncomparative Phase II Trial (PANACHE01 FRENCH08 PRODIGE48 study).

Schwarz L (2025) · Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Preoperative inspiratory muscle training preserved diaphragmatic excursion after esophagectomy: a randomized-controlled trial.

Mizusawa H (2025) · Esophagus : official journal of the Japan Esophageal Society

The efficacy and oncological safety of minimally invasive axillary procedures in patients with node-positive breast cancer receiving neoadjuvant chemotherapy: A network meta-regression and trial sequential analysis.

Lucocq J (2025) · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Unlocking the potential of antioxidant supplementation with n-acetylcysteine to improve seminal parameters and analysis of its safety: a systematic review and meta-analysis of randomized controlled trials.

Syarif S (2025) · Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

Influence of surgical timing post-neoadjuvant chemotherapy on survival outcomes in breast cancer patients: A comprehensive systematic review and meta-analysis.

Wang D (2025) · Breast (Edinburgh, Scotland)

Impact of Heart Failure Severity on Vutrisiran Efficacy in Transthyretin Amyloidosis With Cardiomyopathy.

Maurer MS (2025) · Journal of the American College of Cardiology

Role of Neoadjuvant Chemoradiation Therapy for Resectable and Borderline Resectable Pancreatic Adenocarcinoma-A Systematic Review and Meta-Analysis.

Wu HY (2025) · International journal of radiation oncology, biology, physics

Evaluating the efficacy of N-acetylcysteine in diminishing the duration and frequency of rotavirus-induced gastroenteritis: a preliminary randomized, placebo-controlled, double-blind clinical trial.

Heydari B (2025) · BMC pediatrics

Effect of N-acetylcysteine on antimicrobials induced nephrotoxicity: a meta-analysis.

Qiu X (2025) · BMC nephrology

Developing resistance to Fusarium wilt in chickpea: From identifying meta-QTLs to molecular breeding.

Soorni J (2025) · The plant genome

Comparison of two-bag and three-bag acetylcysteine regimens in the treatment of paracetamol poisoning: a systematic review and meta-analysis.

Nakatsu L (2025) · Clinical toxicology (Philadelphia, Pa.)

Short- and long-term outcomes of neoadjuvant chemotherapy compared with neoadjuvant chemoradiotherapy for locally advanced rectal cancer: an updated meta-analysis.

Guo Y (2025) · BMC gastroenterology

Intratympanic N-acetylcysteine in the prevention of cisplatin-induced ototoxicity: a systematic review and meta-analysis of randomized controlled trials.

Tawalbeh M (2025) · BMC pharmacology & toxicology

N-acetylcysteine antimicrobial action against endodontic pathogens-systematic review and meta-analysis.

Abu Hasna A (2025) · Odontology

Efficacy of N-Acetylcysteine in Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis.

Viña I (2025) · Nutrients

Premedication in upper gastrointestinal endoscopy to improve mucosal visualization. A systematic review.

Linares-Ramírez JD (2024) · Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru

N-Acetylcysteine and Liver Transplant. Advantages of its Administration in Multi-Organ Donors Especially During World-Economical-Crisis. Long-Term Sub-Group Analysis in a Randomized Study.

Finotti M (2025) · Transplantation proceedings

Pretreatment plasma vitamin D and response to neoadjuvant chemotherapy in breast cancer: evidence from pooled analysis of cohort studies.

Shu C (2024) · International journal of surgery (London, England)

Neo-adjuvant FOLFOX with and without panitumumab for patients with KRAS-wt locally advanced colon cancer: results following an extended biomarker panel on the FOxTROT trial embedded phase II population.

Seligmann JF (2025) · Annals of oncology : official journal of the European Society for Medical Oncology

Effects of White Noise Intervention on Sleep Quality and Immunological Indicators of Patients with Breast Cancer Undergoing Neoadjuvant Chemotherapy.

Yin G (2024) · Noise & health

N-acetylcysteine modulates markers of oxidation, inflammation and infection in tuberculosis.

Mapamba DA (2025) · The Journal of infection

Neoadjuvant Endocrine Therapy Compared to Neoadjuvant Chemotherapy in Node-Positive HR+, HER2- Breast Cancer (Nodal pCR and the Rate of ALND): A Systematic Review and Meta-Analysis.

Vasigh M (2024) · The breast journal