Also known as: chasteberry, vitex agnus-castus, chaste tree berry
Latest evidence update: 2025-01-01
Strongest in Consistency (74). Held back by Recency (13).
Solid mix of RCTs with some methodological gaps.
Good cross-study replication, some imprecision.
Thousands of participants across the literature.
Mostly aligned, with some divergence.
Mostly pre-2020 research; updates may be needed.
Effect-size tagged on 108 of 110 claims for this supplement. Our research updates daily; remaining claims are pending re-processing.
Areas where research points to a consistent direction of effect. The strength of evidence is graded; the size of the effect is not quantified.
Recommended: 20-40mg daily
ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.
Significantly reduces premenstrual syndrome symptoms including mood changes, bloating, breast tenderness, and headaches
Relieves cyclic breast pain and tenderness in women of reproductive age
Works as effectively as common medications for treating cyclic breast pain, including dopamine agonists, NSAIDs, hormonal contraceptives, and antidepressants
Does not significantly reduce heavy menstrual bleeding compared to placebo
Is generally well-tolerated with only mild and reversible side effects, though nausea and abdominal pain have been reported in some users