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Collagen Peptides

Also known as: hydrolyzed collagen, collagen peptides, collagen protein

AAdequate Evidence77 studies referenced

Common dosage

10-15g daily

Category

other

Description

Hydrolyzed protein supporting skin elasticity, joint health, and gut lining. Type I/III for skin, Type II for joints.

Safety & interactions

Generally safe. Take with vitamin C for enhanced collagen synthesis.
Check all interactions →

Studies on Collagen Peptides (77)

1.

Oral Collagen Supplementation: A Systematic Review of Dermatological Applications

Choi FD, et al. (2019) · J Drugs Dermatol

Systematic ReviewPubMed
2.

Collagen peptide supplementation in combination with resistance training improves body composition

Zdzieblik D, et al. (2015) · Br J Nutr · n=53

3.

The Promise of Chemotherapy-Free Strategies in Advanced Driver-Negative NSCLC: A Systematic Review and Network Meta-Analysis of Antiangiogenic Combination Therapies.

Li Z (2026) · Cancer medicine

4.

The association between collagen 1a1, NTproBNP and echocardiographic markers in patients with or at risk of HFpEF.

Rastogi T (2026) · International journal of cardiology

5.

The Sustained Effects of Bioactive Collagen Peptides on Skin Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.

Wang Y (2025) · Journal of cosmetic dermatology

6.

Efficacy and Safety of Denosumab and Zoledronic Acid in the Treatment of Postmenopausal Osteoporosis-A Comparative Study of Bone Metabolism, Bone Density, and Sex Hormone Levels.

Tang H (2026) · Journal of applied toxicology : JAT

7.

Population pharmacokinetic/pharmacodynamic model of LY06006 in Chinese healthy subjects and postmenopausal osteoporotic women.

Kuang Y (2026) · British journal of clinical pharmacology

8.

Hibiscus Collagen Alternative (VC-H1) as an Oral Skin Rejuvenating Agent: A 12-Week Pilot Study.

Baek Y (2025) · International journal of molecular sciences · n=98

9.

Nanovesicles for Sensitive Skin Care Developed via Self-Assembly of Glutamine Linoleate.

Kwon KC (2025) · Journal of cosmetic dermatology

10.

Quercetins efficacy on bone and inflammatory markers, body composition, and physical function in postmenopausal women.

Bailly AR (2025) · Journal of bone and mineral metabolism

11.

Blood biomarkers of inflammation and brain-derived neurotrophic factor can not be used to assess the effectiveness of collagen mesotherapy in chronic cervical myofascial pain syndrome. A pilot single-blind randomized study.

Koszela K (2026) · Rheumatology international · n=23

12.

Acute effects of GIP and GLP-1 receptor antagonism in totally pancreatectomized individuals: A randomized double-blind, placebo-controlled crossover study.

Krogh LSL (2026) · Diabetes, obesity & metabolism

13.

Efficacy of Encorelane in Enhancing Barrier Function and Reducing Aging Signs in Sensitive Skin.

Wang L (2025) · Journal of cosmetic dermatology

14.

Effects of cartilage-supporting nutritional supplementation on knee osteoarthritis symptoms and quality of life in a 12-week randomized double-blind placebo-controlled pilot study.

Fladerer-Grollitsch JP (2025) · Scientific reports

15.

Effects of resistance training, Yijinjing and Baduanjin exercise with oral caltrate D on bone mineral density and bone metabolism in older women: a randomised controlled trial.

Yang Y (2025) · BMC complementary medicine and therapies

16.

Feasibility challenges in protein supplementation research: Insights from the convalescence of functional outcomes after intensive care unit stay in a Randomised Controlled Trial.

Paulus MC (2025) · Clinical nutrition (Edinburgh, Scotland)

17.

Efficacy and safety of Vosoritide in achondroplasia: A systematic review and meta-analysis.

Pahuja M (2026) · The Indian journal of medical research · n=156

18.

A Prospective, Randomized, Double-Blind, Split-Face Trial Evaluating the Effects of Pre-Conditioning With a TriHex Technology Serum Nectar 2.0 Versus a Vehicle in Subjects Undergoing Elective Facelift Surgery.

Widgerow AD (2025) · Journal of cosmetic dermatology

19.

Porcine placenta peptides as a complementary functional food for skin rejuvenation: A 12-week randomized, double-blind, placebo-controlled trial.

Nguyen NH (2025) · Complementary therapies in medicine

20.

Acute effect of impact and resistance exercise on Wnt signaling modulators, bone and cartilage metabolism.

Boxer B (2026) · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

21.

Using probiotic supplementation to support bone health in postmenopausal women: a randomized, double-blind, parallel, placebo-controlled, multi-center study.

Yumol JL (2025) · Archives of osteoporosis

22.

Oral Collagen Oligopeptides as a Modulator of Skin Health: A Comprehensive Evaluation of Clinical and Molecular Effects.

Zague V (2025) · Journal of medicinal food

23.

"The effect of aerobic exercise on bone formation and resorption markers and the quality of life tests in postmenopausal osteopenic patients".

Deniz KN (2025) · BMC musculoskeletal disorders

24.

Efficacy of Microneedle Fractional Radiofrequency Combined With Topical Insulin for the Treatment of Facial Atrophic Acne Scars: A Split-Face, Double-Blinded, Randomized, Placebo-Controlled Trial.

Rattananukrom T (2025) · Journal of cosmetic dermatology

25.

Endostatin as a biomarker of systemic sclerosis: insights from a systematic review and meta-analysis.

Mangoni AA (2024) · Frontiers in immunology

26.

Liposomal Delivery Enhances the Effects of a Collagen Tripeptide-Containing Formulation on Dermal Structure and Optical Skin Parameters: A Randomized, Double-Blind, Placebo-Controlled Trial.

Lin YK (2026) · Journal of cosmetic dermatology

27.

Markers of bone turnover after 12 months of exercise in patients with chronic kidney disease 3-5: a post-hoc analysis of RENEXC - a randomized controlled trial.

Petrauskiene V (2025) · BMC nephrology

28.

Clinical Study of Recombinant Human Basic Fibroblast Growth Factor Combined With Collagen Sponge in the Treatment of Maxillofacial Degree II Acute Skin Contusion.

Wang Q (2025) · The Journal of craniofacial surgery

29.

The effects of collagen peptide supplementation on appetite and post-exercise energy intake in females: a randomised controlled trial.

Reynolds KM (2025) · The British journal of nutrition · n=7

30.

Meta-analysis of the synergistic effect of traditional Chinese medicine compounds combined with conventional Western medicine in the treatment of osteoporosis.

Jin H (2025) · Frontiers in endocrinology

31.

A First-In-Human Phase 1 Study to Evaluate the Safety and Tolerability of LEM-S401, a Novel siRNA-DegradaBALL Drug Targeting CTGF in Healthy Adults.

Kim HY (2025) · Clinical and translational science

32.

Evaluation of the effect of 48 weeks of BIC/F/TAF and DRV/c/F/TAF on platelet function in the context of rapid ART start.

Khawaja AA (2025) · HIV research & clinical practice

33.

Effects of Greek Yogurt Versus Whey Protein Supplementation on Markers of Bone Turnover and Inflammation in University Athletes: A 24-Week Intervention Study.

Bell M (2026) · International journal of sport nutrition and exercise metabolism · n=32

34.

P-15 Peptide Enhanced Bone Graft Improves Time to Fusion in Transforaminal Lumbar Interbody Fusion: A Randomized, Controlled, Investigational Device Exemption Study.

Harrop JS (2026) · Spine

35.

Effects of exercise on bone metabolism in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials.

Zhang W (2025) · Frontiers in endocrinology

36.

Stability of Root Coverage Outcomes After Soft-Tissue Augmentation With a Collagen Matrix With or Without rhPDGF-BB: A 3-Year Triple-Blinded, Randomised, Placebo-Controlled Trial.

Tavelli L (2025) · Journal of clinical periodontology

37.

Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial.

Chang H (2025) · Journal of cosmetic dermatology

38.

Plasma chemokines indicate enhanced bleeding in patients with chronic coronary syndrome undergoing percutaneous coronary stenting.

Harm T (2025) · Clinical research in cardiology : official journal of the German Cardiac Society

39.

Effects of protein-rich multi-nutrient intervention on bone mineralization and development: insights from a randomized controlled trial in prepubertal children and a zebrafish experiment.

Xing X (2025) · Food & function

40.

Bone mineral density and bone turnover changes with advanced menstrual recovery: The REFUEL study.

Salamunes ACC (2026) · Bone

41.

Er:YAG and Nd:YAG-based low-level laser therapy (LLLT) with medical collagen improve third-molar extraction wound healing: a randomized controlled trial.

Yuan Z (2025) · Lasers in medical science · n=120

42.

P-15 Peptide Enhanced Bone Graft in Transforaminal Lumbar Interbody Fusion: A Randomized, Controlled, Investigational Device Exemption Study Demonstrating Improved Composite Clinical Success.

Harrop JS (2026) · Spine

43.

Effect of rhPTH(1-34) and alendronate on the treatment of type 2 diabetic bone disease.

Li H (2025) · Frontiers in endocrinology

44.

Skin Anti-Aging and Moisturizing Effects of Low-Molecular-Weight Collagen Peptide Supplementation in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Lee E (2025) · Journal of microbiology and biotechnology

45.

Investigation of the expression of the C-terminal cross-linking telopeptide of type I collagen (CTXI) in saliva during early and delayed loading of dental implants.

Hamid D (2025) · BMC oral health

46.

Glucose-Dependent Insulinotropic Polypeptide Is Involved in Postprandial Regulation of Splanchnic Blood Supply.

Rasmussen RS (2025) · Diabetes

47.

The effect of hyperbaric oxygen therapy on hypospadias reconstruction: a preliminary randomized controlled trial study of VEGF levels and HOPE score analysis.

Oley MH (2025) · Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

48.

Twelve-week interval training alters cytokines, adipokines and bone markers in women with obesity.

Osalou MA (2025) · International journal of sports medicine

49.

Effects of four-weeks porcine-collagen hydrolysate consumption on glucose concentrations, glycemic variability, and fasting/postprandial cardiometabolic risk markers in men and women with overweight or obesity: A randomized, controlled trial.

Chavez-Alfaro MA (2025) · Clinical nutrition (Edinburgh, Scotland)

50.

Effect of pirfenidone on plasma markers of collagen turnover in patients with heart failure, preserved left ventricular ejection fraction and myocardial fibrosis.

Black N (2026) · Open heart

51.

Evaluation of Nile Tilapia (Oreochromis niloticus) Skin Peptides for Wound Healing: A Systematic and Meta-Analysis Review.

Tozetto R (2026) · ACS biomaterials science & engineering

52.

Dietary glycocalyx mimetic reduces vascular risk in Type 2 diabetes: evidence from urinary peptidomic classifiers in a South-Asian Surinamese Cohort.

Biglari S (2025) · Diabetes research and clinical practice

53.

Recombinant Pure PDGF Improves Aesthetic Results and Patient Satisfaction Following RF Microneedling: A Prospective, Randomized, Controlled Clinical Trial.

Lynch SE (2025) · Journal of cosmetic dermatology

54.

Collagen Peptide Supplementation Enhances Muscle-Tendon Stiffness and Explosive Strength: A 16-wk Randomized Controlled Trial.

Miyamoto N (2025) · Medicine and science in sports and exercise

55.

Can supplements with prebiotic fibres positively influence bone health in type 2 diabetes? Insights from a randomised controlled crossover trial.

Birkeland E (2025) · Archives of osteoporosis

56.

The effect of supplementation with type I and type III collagen peptide and type II hydrolyzed collagen on pain, quality of life and physical function in patients with meniscopathy: a randomized, double-blind, placebo-controlled study.

Genç AS (2025) · BMC musculoskeletal disorders

57.

Bone Turnover Markers (CTX and P1NP) Following Low-Carbohydrate and Mediterranean Diet Interventions in Adolescents and Young Adults with Type 1 Diabetes.

Levran N (2025) · Nutrients · n=20

58.

Dileucine-supplemented essential amino acids support whole-body anabolism after resistance exercise and serum-stimulated cell-based anabolism.

Aguilera JA (2025) · Journal of the International Society of Sports Nutrition

59.

Effects of porcine-derived collagen hydrolysates on 24 h blood pressure profiles, markers for endothelial dysfunction and low-grade inflammation and the retinal vasculature in adults with overweight/obesity: a randomized, controlled trial.

Chavez-Alfaro MA (2025) · Food & function

60.

Phase II INTEGRIS-PSC trial of bexotegrast, an αvβ6/αvβ1 integrin inhibitor, in primary sclerosing cholangitis.

Hirschfield GM (2026) · Journal of hepatology

61.

A Randomized, Double-Blind, Split-Face, Clinical Trial of Angiopoietin-1 Derived Peptide Topical Following Fractional Radiofrequency Microneedling.

Giorgio CD (2025) · Journal of drugs in dermatology : JDD

62.

Unravelling the bioavailability of amino acids and bioactive peptides from collagen hydrolysate in coffee in healthy volunteers.

Virgilio N (2025) · Food research international (Ottawa, Ont.)

63.

Tissue Perfusion and Biomarkers Assessment Following Root Coverage Procedures.

Tavelli L (2025) · Journal of periodontal research

64.

Effects of Greek Yogurt Supplementation and Exercise on Markers of Bone Turnover and Inflammation in Older Adult Exercisers: An 8-Week Pilot Intervention Trial.

Bell M (2025) · Nutrients

65.

Regular collagen peptide administration exerts anti-obesity effects in high-caloric diet-fed rodents-a systematic review with meta-analysis of animal trials.

Bischof K (2026) · International journal of obesity (2005)

66.

Efficacy and safety of Rh-endostatin in the treatment of radiation pneumonitis in non-small cell lung cancer.

Chen G (2025) · The oncologist

67.

Efficacy of combined undenatured type II collagen and hydrolysed collagen supplementation in knee osteoarthritis: a randomised controlled trial.

Yuenyongviwat V (2025) · Scientific reports · n=68

68.

Relationship between homocysteine levels and bone quality in healthy adults - A systematic review and meta-analysis.

Sharma DK (2025) · Clinical nutrition ESPEN

69.

Identifying a predictive level of serum C-terminal telopeptide associated with a low risk of medication-related osteonecrosis of the jaw secondary to oral surgery: A systematic review and meta-analysis.

Ghio C (2025) · PloS one

70.

Bone turnover markers predict changes in bone mineral density in men treated with abaloparatide: results from the abaloparatide for the treatment of men with osteoporosis (ATOM) study.

Eastell R (2025) · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

71.

[Evaluation of the clinical effect of concentrated growth factor combined with sticky bone in maxillary anterior alveolar ridge preservation].

Wei X (2025) · Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology

72.

Collagen Supplementation Augments Strength Training-Induced Gains in Tendon Size and Rate of Force Development in Elite Female Master Field Hockey Athletes.

Nulty CD (2025) · International journal of sport nutrition and exercise metabolism · n=10

73.

The Separate and Combined Effects of GIP, GLP-1, and GLP-2 on Markers of Bone Turnover in Type 2 Diabetes.

Hansen JV (2026) · The Journal of clinical endocrinology and metabolism

74.

Long-Term Treatment Outcomes of Peri-Implantitis Reconstructive Therapy: 7-Year Survival and Success of a Randomized Clinical Trial.

Isler SC (2025) · Clinical oral implants research

75.

Belumosudil reduces oral chronic graft-versus-host disease tissue inflammation and fibrosis: a ROCKstar companion study.

Sharma R (2025) · Blood advances · n=14

76.

Hydrolysed Collagen Supplementation Enhances Patellar Tendon Adaptations to 12 Weeks' Resistance Training in Middle-Aged Men.

Nulty CD (2025) · European journal of sport science

77.

Treatment of postmenopausal osteoporosis with recombinant human parathyroid hormone and electromagnetic field.

Xuan M (2025) · Aging clinical and experimental research

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