NMN (Nicotinamide Mononucleotide)

Also known as: NMN, beta-NMN

Confidence

research strength

BBuilding confidence6225 studies referenced

Latest evidence update: 2026-12-31

Strongest in Recency (73). Held back by Consistency (38).

Study quality (37%)

Study design (21%)

Risk of bias (16%)

Solid mix of RCTs with some methodological gaps.

Replication (26%)

Cross-study replication (21%)

Precision (5%)

Good cross-study replication, some imprecision.

Sample size (16%)

Thousands of participants across the literature.

Consistency (11%)

Mixed direction across studies.

Recency (10%)

Healthy mix of recent and established research.

Effect by outcome

how big the change is

Longevity & aging Metabolic health

Common dosage

250-500mg daily

Description

NAD+ precursor being studied for cellular energy production and longevity. Human evidence is early but promising.

Safety & interactions

Long-term human safety data is limited. Take in the morning — may interfere with sleep if taken late.

Check interactions with other supplements→

What the research shows

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Order NMN (Nicotinamide Mononucleotide)

Recommended: 250-500mg daily

Protocols featuring NMN (Nicotinamide Mononucleotide)

Foundational Longevity StackASolid confidence

Questions about NMN (Nicotinamide Mononucleotide)

Who has been studied for NMN (Nicotinamide Mononucleotide)?

Who should avoid NMN (Nicotinamide Mononucleotide) based on the safety notes?

What dose did studies use for NMN (Nicotinamide Mononucleotide), and when was it taken?

Referenced studies (25)

ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.

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Increases blood NAD+ levels in adults

strong evidence2 studies:Nature metabolism (2026)Critical reviews in food science and nutrition (2025)

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Does not significantly improve blood sugar control, cholesterol levels, or insulin sensitivity in most adults

strong evidence2 studies:Critical reviews in food science and nutrition (2025)Current diabetes reports (2024)

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Does not improve muscle strength, mass, or physical performance in older adults

strong evidence1 study:Journal of cachexia, sarcopenia and muscle (2025)

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May improve aerobic exercise performance and oxygen utilization during training

emerging evidence1 study:Journal of the International Society of Sports Nutrition (2021)