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Evidence-based protocols for every health goal, updated daily.

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ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.

© 2026 ProtocolEngine

A healthier you.
Made personal.

Habits, food, and supplements built around your goals.

It only takes two minutes.

Get your protocol Browse all protocols

Free to start. 30,000+ studies analyzed.

How it works

Tell us about you

Two minutes. Your goals, routine, and constraints.

S TIER

Get your protocol

Habits, food, and supplements matched to your goals. Each one scored by the evidence.

Live it

Schedule habits. Order supplements. Your protocol updates as new research lands.

Take the quiz
“
Every recommendation on this site links back to the studies behind it. No exceptions.
Our transparency pledge

What published research has found

These findings come from peer-reviewed studies published in the Lancet, NEJM, BMJ, and JAMA.

A living research engine

Our pipeline reads every new study daily, extracts health claims, and recalculates evidence scores. Your protocol always reflects the full body of research.

Last 24 hours

0

papers analyzed

Last 30 days

0

papers analyzed

Total

0

papers in our database

142 supplements tracked·65 habits monitored·34 protocols available

Exhaustive, not selective

Every study on every supplement, food, and habit we track is analyzed. Not a sample. Not a summary.
All of it (since 2010).

Transparent scoring

Six-factor evidence grades you can inspect. See exactly why a recommendation is rated
S, A, B, C, D, or E. Tier-list style.

PubMed, bioRxiv, medRxiv

Peer-reviewed sources only

GRADE framework

Cochrane-informed scoring

GDPR compliant

EU-hosted, Berlin-based

Stripe-secured payments

PCI Level 1 certified

Transparency

Every claim graded. Every source cited.

Our Evidence Assistant draws on 40197+ analyzed papers to build your protocol. Every recommendation includes its evidence grade and the studies behind it.

"Studies show" is the most abused phrase in health.

Every recommendation here links to the specific paper, journal, sample size, and study type. Click through and verify it yourself.

Half of supplement users risk at least one interaction they don't know about.

We screen your full stack for conflicts, timing issues, and absorption blockers before you take anything.

That study you read in 2021 may already be outdated.

Our pipeline checks PubMed daily. When a new meta-analysis shifts the evidence, your protocol updates automatically.

Protocol output

Morning Optimization Protocol

3 supplements · 3 habits

1

Morning sunlight exposure

habit

Within 30 min of waking

2

Cold exposure

Premium

Go from reading to doing.

The science is free. The action is Premium.

Premium turns your protocol into a system. Schedule habits into your calendar, order supplements in one click, and track what's working — all powered by the latest research.

Schedule to calendar

Map your protocol onto your week. Habits auto-scheduled, supplements timed. Export to any calendar app.

Personalized meal plans

153+ evidence-based recipes matched to your macros and goals. Total Daily Energy Expenditure calculator, weekly meal plans, and auto-generated shopping lists grouped by grocery aisle.

Evidence alerts

Get notified when new research changes the score on supplements you take. Your protocol stays current.

Wearables integration

Connect Oura, Garmin, Whoop, Apple Health and more. Your sleep, HRV, activity, and recovery flow into the dashboard so the protocol can adapt to how you actually slept and trained — not what you planned.

Weekly digest includes

New research findings

448 papers analyzed this week

Evidence grade changes

Know when the science shifts

Actionable takeaways

What changed and why it matters

The weekly evidence digest

A weekly summary of what changed in health science, which evidence scores shifted, and what you should know. No spam, no hype.

Roadmap

What's coming next

✓

Live now

Evidence-graded protocols

Supplements and habits scored by research quality. Personalized quiz. Evidence Assistant. Calendar scheduling.

✓

Live now

Diet optimization

156 evidence-based recipes, personalized meal plans, TDEE calculator, shopping lists, and food-supplement synergies.

✓

Live now

Sync your wearable

Connect Oura or Withings. Your sleep, recovery, and readiness trends become evidence-graded protocol suggestions, each one linked to the studies behind it.

✓

Live now

Bloodwork analysis

Upload your lab results to unlock a protocol built around your actual biomarkers. Personalized to what your blood shows, not just your goals.

5

Coming soon

Mobile app

Take your protocol with you. Log habits, log doses, and review evidence on iOS and Android, in sync with the web.

Always current

When new research shifts the evidence, your protocol reflects it. Yesterday's science is already in the system.

Scoring informed by GRADE & Cochrane frameworks. Updated daily from PubMed, bioRxiv, and medRxiv. Database covers research from 2010 to present.

habit

After waking

3

Morning exercise

habit

After cold exposure

4

Vitamin D3

supplement

5000 IU + K2 100mcg

5

Omega-3 (EPA/DHA)

supplement

2g EPA/DHA

6

Creatine Monohydrate

supplement

5g

Get yours in 2 minutes
Evidence extraction
ProbioticsSHigh confidence

496 studies referenced

See full evidence profile
CurcuminSHigh confidence

487 studies referenced

See full evidence profile
Omega-3 (EPA/DHA)SHigh confidence

485 studies referenced

See full evidence profile
Evidence Assistant
I'm stressed, sleeping poorly, and want more energy during the day.
Based on your profile, magnesium glycinate before bed would help with both. Three meta-analyses across 900+ participants show 300-400mg reduces sleep onset time by about 17 minutes. For daytime energy, your vitamin D levels are worth checking first.
I take iron supplements. Any interactions I should know about?
Good question. Take magnesium and iron at least 2 hours apart, they compete for absorption. Morning iron, evening magnesium works well with your schedule.
Get your protocol Browse curated protocols

Not ChatGPT for supplements

Every answer is grounded in our graded research database. No invented citations. No 'sounds plausible' guesses. Knows your stack, names the grades.

Smart stack intelligence

Synergies you're missing, gaps in your stack, conflicts to avoid. Not just warnings — opportunities.

Progress journal

Simple daily check-ins. See how protocol changes correlate with how you feel over time.

Start 14-day free trial See pricing

14 days free. 30-day money-back guarantee. Cancel anytime.

6

Coming soon

Genetic analysis

Upload your genotype data to unlock a protocol built around your DNA. Personalized to your genetic variants, not just your goals and bloodwork.

90%

of heart attacks trace to 9 modifiable lifestyle factors

INTERHEART study, 52 countries, 29,000 participants

45%

of dementia cases are attributable to lifestyle factors

Lancet Commission 2024, 14 modifiable risk factors

60%

of type 2 diabetes is preventable through lifestyle changes alone

Diabetes Prevention Program, 3,000+ participants

As effective

Exercise matches medication for mild-to-moderate depression

BMJ 2024, network meta-analysis of 218 RCTs

30%

reduction in cardiovascular events through diet optimization

PREDIMED trial, 7,447 participants over 4.8 years

1 in 2

people have insufficient vitamin D levels worldwide

Global meta-analysis of population studies