Nattokinase

Also known as: natto enzyme, subtilisin NAT, NSK-SD

CCautionary466 studies referenced

Latest evidence update: 2026-01-29

Cardiovascular health

Common dosage

2000-4000 FU daily

Description

Fibrinolytic enzyme derived from natto (fermented soybean). Evidence for reducing blood clot formation, lowering blood pressure, and improving circulation. Unique mechanism of action distinct from other cardiovascular supplements.

Safety & interactions

Do NOT combine with blood thinners (warfarin, aspirin). Discontinue 2 weeks before surgery. Contraindicated in bleeding disorders.

Check interactions with other supplements→

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Recommended: 2000-4000 FU daily

Questions about Nattokinase

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Referenced studies (6)

ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.