Also known as: natto enzyme, subtilisin NAT, NSK-SD
Latest evidence update: 2026-01-29
Strongest in Study quality (65). Held back by Replication (27).
Solid mix of RCTs with some methodological gaps.
Few independent replications; results not yet robust.
Small combined sample; treat as preliminary.
Mixed direction across studies.
Evidence base skews older; field may have moved on.
No quantified outcomes yet. Once we have studies with measurable endpoints, you will see per-outcome magnitude here.
Recommended: 2000-4000 FU daily
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