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CoQ10 (Ubiquinol)

Also known as: coenzyme Q10, ubiquinone, ubiquinol

AAdequate Evidence30 studies referenced

Common dosage

100-200mg daily

Category

other

Description

Mitochondrial coenzyme essential for cellular energy production. Levels decline with age and statin use. Ubiquinol form is better absorbed.

Safety & interactions

Take with fat. Ubiquinol form preferred over ubiquinone for adults over 40.
Check all interactions →

Studies on CoQ10 (Ubiquinol) (30)

1.

Coenzyme Q10 supplementation reduces oxidative stress and decreases antioxidant enzyme activity

Garrido-Maraver J, et al. (2014) · Biofactors

ReviewPubMed
2.

Effect of coenzyme Q10 on blood pressure: a meta-analysis

Ho MJ, et al. (2009) · J Hum Hypertens · n=432

Meta-analysisPubMed
3.

Effects of Coenzyme Q10 Supplementation on Glycemic Control Biomarkers: An Umbrella Review of Meta-Analyses of Randomised Controlled Trials.

Musazadeh V (2026) · Endocrinology, diabetes & metabolism

4.

Effects of Ubiquinol on Oxidized Low-Density Lipoprotein in Prediabetic Patients: A Randomized, Double-Blinded, Placebo-Controlled Study.

Leaovitavat R (2026) · BioMed research international

5.

Coenzyme Q10 Impact on Ovarian Reserve Measures and the Intra-Cytoplasmic Sperm Injection (ICSI) Outcomes in Women with Poor Ovarian Response: A Randomized Controlled Study.

Abdelrahman MA (2026) · Drug design, development and therapy

6.

A Randomized, Double-Blind, Two-Treatment, Two-Period, Crossover Study Investigating the Systemic Bioavailability of a Novel Cocrystal Ubiquinol Formulation Compared with a Ubiquinone Formulation in Healthy Adults.

Mei X (2026) · Clinical pharmacology in drug development

7.

Translational studies of chronic supplementation with a mitochondria-targeted antioxidant to improve physical function with ageing.

Murray KO (2026) · The Journal of physiology

8.

Next-generation liposomal coenzyme Q10: from formulation to clinical evidence via metazome technology for improved stability and enhanced oral absorption.

Amalraj A (2026) · Food & function

9.

Effect of micronutrients on fertility and aneuploidy rates in human conceptions: a systematic review and meta-analysis.

Schütz D (2026) · Reproductive biomedicine online

10.

Effects of Coenzyme Q10 Supplementation on Physical Function Adaptations to High-Intensity Interval Training in Older Adults.

Bagheri N (2025) · Nutrients · n=38

11.

Effectiveness of Liquid Toothpaste Containing Coenzyme Q10 in Reducing Dental Plaque and Gingivitis: A Crossover Randomized Controlled Trial.

Buranasin P (2025) · The journal of contemporary dental practice

12.

MitoQ supplementation does not impact redox responses to acute exercise in skeletal muscle of older individuals.

Broome SC (2025) · Redox biology

13.

Effects of Coenzyme Q10 Supplementation on Depressive Symptoms and Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Magalhães PLM (2025) · Journal of clinical psychopharmacology

14.

Phase I Randomized, Placebo-Controlled, Cross-Over Dose-Finding Study of Coenzyme Q10 on Doxorubicin Pharmacokinetics during Breast Cancer Treatment.

Greenlee H (2025) · Integrative cancer therapies

15.

The auxiliary effect of oral nutritional supplements on fertility in women with diminished ovarian reserve: a systematic review and meta-analysis.

Li X (2025) · Annals of medicine

16.

Bioavailability and Cellular Compatibility of a Novel Coenzyme Q10 Emulgel as an Alternative Oral Delivery System for Patients with Dysphagia: Preliminary Results from a Randomized Study.

Avila AC (2026) · European journal of drug metabolism and pharmacokinetics

17.

Efficacy Of Combined Nutritional And Pharmacological Interventions In PCOS: A Six Month Randomized Controlled Trial.

Zahra M (2026) · Naunyn-Schmiedeberg's archives of pharmacology

18.

The clinical outcome of Montelukast versus co-enzyme Q10 in adult patients with sepsis: A randomized controlled clinical trial.

Eladly GH (2026) · Journal of critical care

19.

The effect of coenzyme Q10 supplementation on depressive symptoms and anxiety: a systematic review and meta-analysis of randomized controlled trials.

Akwan R (2025) · European journal of clinical pharmacology

20.

A pilot double-blind, placebo-controlled, randomized clinical trial of MitoQ in the treatment of septic shock: evaluating its effects on clinical outcomes and oxidative stress biomarker.

Moradbaki H (2026) · Naunyn-Schmiedeberg's archives of pharmacology

21.

Effects of Carnitine and Coenzyme Q10 on Sperm Quality and Pregnancy Rates in Men with Unexplained Infertility: A Systematic Review and Network Meta-Analysis.

Niu C (2025) · Reproductive sciences (Thousand Oaks, Calif.)

22.

Therapeutic benefit of idebenone in Leber hereditary optic neuropathy: a systematic review and meta-analysis.

Ribeiro PVZ (2025) · Ophthalmic genetics

23.

Effect of coenzyme Q10 on post-extraction tissue healing in wisdom tooth Surgery: double-blind randomized clinical trial.

Nejati Z (2025) · Pain management

24.

Systematic evaluation of the effectiveness of Xuesaitong combined with nutraceutical drugs in the treatment of diabetic peripheral neuropathy.

Li J (2025) · Pakistan journal of pharmaceutical sciences

25.

Comparative Efficacy of Nutritional Supplements in Modulating Lung Function and Exercise Capacity in COPD Patients: A Network Meta-Analysis.

Zeng Y (2025) · International journal of chronic obstructive pulmonary disease

26.

The effects of various nutritional supplements in patients with chronic obstructive pulmonary disease: a network meta-analysis.

Zeng J (2025) · BMC pulmonary medicine

27.

Idebenone vs. rAAV2-ND4 gene therapy in the treatment of Leber's hereditary optic neuropathy: An indirect comparison meta-analysis.

Hassan AK (2025) · Indian journal of ophthalmology · n=645

28.

Dietary intake of coenzyme Q10 reduces oxidative stress in patients with acute ischemic stroke: a double-blind, randomized placebo-controlled study.

Mojaver A (2025) · Neurological research

29.

Clinical efficacy of adjunctive use of coenzyme Q10 in non-surgical periodontal treatment: A systematic review.

Fernandez MDS (2025) · European journal of oral sciences

30.

Effects of Coenzyme Q10 Supplementation on Metabolic Indicators in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis.

Li Y (2025) · Clinical therapeutics

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