Also known as: Potassium citrate, Potassium chloride
Latest evidence update: 2026-04-05
Strongest in Sample size (83). Held back by Recency (47).
Solid mix of RCTs with some methodological gaps.
Confirmed across many independent studies with significant findings.
Tens of thousands of participants pooled across studies.
Mostly aligned, with some divergence.
Evidence base skews older; field may have moved on.
Effect-size tagged on 342 of 362 claims for this supplement. Our research updates daily; remaining claims are pending re-processing.
Areas where research points to a consistent direction of effect. The strength of evidence is graded; the size of the effect is not quantified.
Recommended: Varies by form and individual needs
ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.
Reduces blood pressure in people with hypertension and modestly lowers it in people with normal blood pressure, with greater effects at higher sodium intakes
Improves blood vessel function and endothelial health, which supports cardiovascular circulation
Using salt substitutes with moderate potassium and low sodium reduces cardiovascular events and mortality compared to regular salt
Reduces bone resorption and lowers acid levels in urine, which may support bone health
Helps people with high potassium levels in their blood safely tolerate heart and kidney medications by lowering excess potassium