Also known as: N-acetyl-5-methoxytryptamine
Latest evidence update: 2026-07-15
Strongest in Sample size (95). Held back by Recency (37).
Solid mix of RCTs with some methodological gaps.
Confirmed across many independent studies with significant findings.
Tens of thousands of participants pooled across studies.
Mostly aligned, with some divergence.
Evidence base skews older; field may have moved on.
Effect-size tagged on 392 of 400 claims for this supplement. Our research updates daily; remaining claims are pending re-processing.
Areas where research points to a consistent direction of effect. The strength of evidence is graded; the size of the effect is not quantified.
Recommended: 0.3-1mg before bed
ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.
Improves sleep quality and sleep efficiency in people with cognitive impairment and shift workers
Enhances cognitive function and mental health in older adults with cognitive impairment
Reduces menopause symptoms and improves sleep in female shift workers
Helps prevent delirium in hospitalized older adults
Improves sleep and behavior in children with cerebral palsy