Also known as: Branched-Chain Amino Acids, Leucine, Isoleucine, Valine
Latest evidence update: 2026-05-18
Strongest in Sample size (86). Held back by Recency (27).
Solid mix of RCTs with some methodological gaps.
Confirmed across many independent studies with significant findings.
Tens of thousands of participants pooled across studies.
Mostly aligned, with some divergence.
Mostly pre-2020 research; updates may be needed.
Effect-size tagged on 395 of 400 claims for this supplement. Our research updates daily; remaining claims are pending re-processing.
Areas where research points to a consistent direction of effect. The strength of evidence is graded; the size of the effect is not quantified.
Recommended: Varies by form and individual needs
ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.
May increase type 2 diabetes risk, particularly when consumed as dietary supplements rather than whole foods
Shows beneficial effects for hepatic encephalopathy symptoms, with greater benefits for severe cases than mild cases
May help maintain muscle mass and improve physical function in older adults, particularly when combined with resistance training
May improve nutritional status and reduce fluid buildup in patients with liver disease undergoing medical procedures
May reduce infection risk after cancer surgery but shows no clear benefit for other surgical outcomes