Also known as: Copper gluconate, Copper bisglycinate
Latest evidence update: 2026-02-01
Strongest in Sample size (94). Held back by Recency (29).
Solid mix of RCTs with some methodological gaps.
Confirmed across many independent studies with significant findings.
Tens of thousands of participants pooled across studies.
Mostly aligned, with some divergence.
Mostly pre-2020 research; updates may be needed.
No per-outcome numbers yet for this one. Each finding's direction and strength is shown in the research below.
Areas where research points to a consistent direction of effect. The strength of evidence is graded; the size of the effect is not quantified.
Recommended: Varies by form and individual needs
ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.
Higher copper levels are associated with increased cancer risk and tumor progression
Copper supplementation has no significant effect on blood cholesterol levels
Higher copper and lower zinc levels are associated with autism spectrum disorder
Elevated copper levels are associated with depression and heart failure
Higher dietary copper intake is associated with modest improvements in bone mineral density