Also known as: choline alfoscerate, L-alpha glycerylphosphorylcholine
Latest evidence update: 2025-12-01
Strongest in Study quality (68). Held back by Sample size (42).
Solid mix of RCTs with some methodological gaps.
Some independent replication, statistical precision uneven.
Hundreds of participants; meaningful but not large.
Mixed direction across studies.
Evidence base skews older; field may have moved on.
No quantified outcomes for Alpha-GPCyet. Once the corpus has studies with measurable endpoints, you'll see per-outcome magnitude here.
Recommended: 300-600mg daily
ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.
Improves cognitive function and memory in people with mild cognitive impairment, particularly when combined with other cognitive-supporting medications
Enhances attention and mental processing speed in healthy individuals
Increases motivation and drive
Improves heart rate variability and supports faster cardiovascular recovery after intense exercise
Enhances endurance exercise performance when combined with other amino acids and supplements