Also known as: vit K, vitamin K supplementation
Latest evidence update: 2025-12-30
Strongest in Sample size (95). Held back by Recency (50).
Solid mix of RCTs with some methodological gaps.
Confirmed across many independent studies with significant findings.
Tens of thousands of participants pooled across studies.
Mostly aligned, with some divergence.
Evidence base skews older; field may have moved on.
Effect-size tagged on 395 of 400 claims for this supplement. Our research updates daily; remaining claims are pending re-processing.
Areas where research points to a consistent direction of effect. The strength of evidence is graded; the size of the effect is not quantified.
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Specific salts and chemical forms studied in research. Bioavailability, dose, and clinical use case differ across forms. See each form's page for form-specific evidence.
ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.
Reduces bleeding risk compared to vitamin K antagonists in patients with heart conditions requiring blood thinning treatment
Lowers stroke and blood clot risk compared to vitamin K antagonists in patients with irregular heart rhythm
Reduces brain bleeding risk compared to vitamin K antagonists in patients with blood clots in the brain
May help prevent type 2 diabetes when vitamin K levels are adequate or supplementation is used
May improve insulin sensitivity when vitamin K is supplemented in people with metabolic conditions