Urolithin A

Also known as: UA, mitopure

BBuilding Evidence6227 studies referenced

Latest evidence update: 2026-05-12

Longevity & aging Exercise & movement

Common dosage

500-1000mg daily

Description

Gut metabolite of ellagitannins (found in pomegranates). Potent inducer of mitophagy -- the selective recycling of damaged mitochondria. Animal studies show improved muscle function and extended healthspan.

Safety & interactions

GRAS status. Well-tolerated in human safety trials. Most people cannot produce urolithin A efficiently from diet alone, hence supplementation.

Check interactions with other supplements→

What the research shows

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Order Urolithin A

Recommended: 500-1000mg daily

Questions about Urolithin A

Who has been studied for Urolithin A?

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What dose did studies use for Urolithin A, and when was it taken?

Referenced studies (27)

ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.

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Increases muscle strength and endurance performance in resistance-trained athletes

strong evidence1 study:Journal of the International Society of Sports Nutrition (2024)

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Improves physical performance and aerobic endurance in middle-aged adults

moderate evidence1 study:JAMA network open (2022)

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Enhances mitochondrial health and function in muscle tissue