Also known as: CDP-choline, cytidine diphosphocholine
Latest evidence update: 2026-06-01
Strongest in Consistency (80). Held back by Recency (19).
Solid mix of RCTs with some methodological gaps.
Good cross-study replication, some imprecision.
Thousands of participants across the literature.
Studies agree on direction of effect.
Mostly pre-2020 research; updates may be needed.
No quantified outcomes for Citicolineyet. Once the corpus has studies with measurable endpoints, you'll see per-outcome magnitude here.
Recommended: 250-500mg daily
ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.
May improve functional recovery and independence in acute ischemic stroke patients who are not treated with clot-busting therapy
Does not improve cognitive outcomes, neurological function, or survival in traumatic brain injury patients
May reduce symptoms in schizophrenia and improve sensory processing in certain patient subgroups
Improves memory and concentration in healthy older adults and those with mild cognitive impairment
Improves vision-related outcomes in eye conditions including reduced seizures in newborns with lack of oxygen to the brain and faster corneal healing after eye surgery