Also known as: HA, oral hyaluronic acid, hyaluron, hyaluronan
Latest evidence update: 2026-06-25
Strongest in Sample size (84). Held back by Recency (39).
Solid mix of RCTs with some methodological gaps.
Confirmed across many independent studies with significant findings.
Tens of thousands of participants pooled across studies.
Studies agree on direction of effect.
Evidence base skews older; field may have moved on.
Effect-size tagged on 395 of 400 claims for this supplement. Our research updates daily; remaining claims are pending re-processing.
Areas where research points to a consistent direction of effect. The strength of evidence is graded; the size of the effect is not quantified.
Recommended: 120-240mg daily
ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.
Improves lip appearance and fullness with high patient satisfaction rates
Reduces knee osteoarthritis pain when combined with other treatments
Common side effects from lip injections include swelling, bruising, firmness, and tenderness
May increase risk of serious adverse events when injected into joints compared to placebo
Provides modest improvements to gum health when used alongside periodontal treatment