Also known as: pyridoxine, pyridoxal-5-phosphate, P5P
Latest evidence update: 2026-03-07
Strongest in Sample size (95). Held back by Recency (23).
Solid mix of RCTs with some methodological gaps.
Confirmed across many independent studies with significant findings.
Tens of thousands of participants pooled across studies.
Mostly aligned, with some divergence.
Mostly pre-2020 research; updates may be needed.
Recommended: 25-50mg daily
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May help reduce stroke risk when combined with other B vitamins, with greater benefits at higher doses and longer treatment duration
Reduces nausea and vomiting during pregnancy and when used with chemotherapy treatment
Higher blood levels are associated with reduced risk of several cancers including breast, pancreatic, and gastrointestinal cancers
Does not improve cognitive function or prevent cognitive decline in elderly people or those with dementia, despite lowering homocysteine levels
Does not reduce major cardiovascular events or cardiovascular-related death in people with heart disease, despite lowering homocysteine