Latest evidence update: 2026-04-27
Strongest in Consistency (95). Held back by Sample size (42).
Solid mix of RCTs with some methodological gaps.
Good cross-study replication, some imprecision.
Hundreds of participants; meaningful but not large.
Studies agree on direction of effect.
Evidence base skews older; field may have moved on.
No per-outcome numbers yet for this one. Each finding's direction and strength is shown in the research below.
Areas where research points to a consistent direction of effect. The strength of evidence is graded; the size of the effect is not quantified.
Recommended: 100-500mg daily or intermittent high-dose (senolytic protocol)
ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.
Reduces cellular aging markers and extends lifespan in animals, particularly when used intermittently later in life
Improves blood vessel function and reduces arterial stiffness by decreasing cellular senescence
Reduces inflammation markers and supports better outcomes in obese individuals when combined with exercise training
May help reduce inflammation in cancer patients undergoing chemotherapy, particularly reducing a key inflammatory marker
Protects against oxidative stress damage by activating the body's natural antioxidant defenses