Centrophenoxine

Also known as: meclofenoxate, lucidril

Confidence

research strength

DPreliminary141 studies referenced

Latest evidence update: 1973-12-01

Strongest in Consistency (35). Held back by Sample size (5).

Study quality (37%)

Study design (21%)

Risk of bias (16%)

Limited to weak study designs or thin reporting.

Replication (26%)

Cross-study replication (21%)

Precision (5%)

Few independent replications; results not yet robust.

Sample size (16%)

Small combined sample; treat as preliminary.

Consistency (11%)

Mixed direction across studies.

Recency (10%)

Mostly pre-2020 research; updates may be needed.

Effect by outcome

how big the change is

No quantified outcomes yet. Once we have studies with measurable endpoints, you will see per-outcome magnitude here.

Cognitive performance Longevity & aging

Common dosage

Research doses: 250–1000 mg/day in older animal/clinical literature

Description

Cholinergic compound (DMAE bonded to a chlorophenoxyacetate carrier) studied for cognitive aging and lipofuscin clearance. Best-known for animal studies showing reduction of age-pigment lipofuscin in neurons and modest lifespan extension in mice. Human evidence is decades-old and methodologically limited.

Safety & interactions

Old literature reports occasional GI upset, headache, insomnia. Not approved as a supplement in many jurisdictions. Avoid in seizure disorders.

Check interactions with other supplements→

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Order Centrophenoxine

Recommended: Research doses: 250–1000 mg/day in older animal/clinical literature

Questions about Centrophenoxine

Who should avoid Centrophenoxine based on the safety notes?

What dose did studies use for Centrophenoxine, and when was it taken?

What does the research actually show Centrophenoxine does?

Referenced studies (1)

ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.