Also known as: wheat germ extract
Latest evidence update: 2026-04-08
Strongest in Consistency (85). Held back by Sample size (30).
Solid mix of RCTs with some methodological gaps.
Some independent replication, statistical precision uneven.
Small combined sample; treat as preliminary.
Studies agree on direction of effect.
Evidence base skews older; field may have moved on.
No quantified outcomes for Spermidineyet. Once the corpus has studies with measurable endpoints, you'll see per-outcome magnitude here.
Recommended: 1-2mg daily
ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.
May improve memory and cognitive performance in older adults with mild dementia or cognitive decline
May reduce brain inflammation and support cellular cleanup processes related to dementia
May reduce inflammatory markers and oxidative stress in the immune system
High-dose spermidine supplementation does not significantly increase spermidine levels in the bloodstream in healthy adults
Is well-tolerated with no serious adverse effects reported at supplementation doses up to 40 mg daily