Also known as: wheat germ extract
Latest evidence update: 2026-04-08
Strongest in Consistency (84). Held back by Recency (52).
Solid mix of RCTs with some methodological gaps.
Some independent replication, statistical precision uneven.
Thousands of participants across the literature.
Studies agree on direction of effect.
Evidence base skews older; field may have moved on.
No per-outcome numbers yet for this one. Each finding's direction and strength is shown in the research below.
Areas where research points to a consistent direction of effect. The strength of evidence is graded; the size of the effect is not quantified.
Recommended: 1-2mg daily
ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.
May improve memory and cognitive performance in older adults with mild dementia or cognitive decline
May reduce brain inflammation and support cellular cleanup processes related to dementia
May reduce inflammatory markers and oxidative stress in the immune system
High-dose spermidine supplementation does not significantly increase spermidine levels in the bloodstream in healthy adults
Is well-tolerated with no serious adverse effects reported at supplementation doses up to 40 mg daily