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Vitamin C

Also known as: ascorbic acid, sodium ascorbate

SStrong Evidence19 studies referenced

Common dosage

500-1000mg daily

Category

vitamin

Description

Antioxidant vitamin supporting immune function, collagen synthesis, and iron absorption. Benefits are most pronounced in those under physical stress.

Safety & interactions

May cause GI upset at high doses. Liposomal form has better absorption.
Check all interactions →

Studies on Vitamin C (19)

1.

Vitamin C for preventing and treating the common cold

Hemilä H, Chalker E (2013) · Cochrane Database Syst Rev · n=11,306

Meta-analysisPubMed
2.

Vitamin C and Immune Function

Carr AC, Maggini S (2017) · Nutrients

ReviewPubMed
3.

Meta-analysis of randomized controlled trials: efficacy of vitamin C mesotherapy for gingival hyperpigmentation in adults.

Hu M (2025) · BMC oral health

4.

Causal effects of dietary antioxidants on epigenetic age: A two-sample Mendelian randomization study.

Huang C (2025) · Medicine

5.

Effect of Using Vitamin C Supplementation on Performance, Blood Parameters, Carcass Characteristics and Meat Quality of Broiler Chickens Under Heat Stress Condition: A Meta-Analysis.

Tavakolinasab F (2025) · Journal of animal physiology and animal nutrition

6.

Comparative Cleansing Efficacy, Safety, and Tolerability of Bowel Preparation Agents in Pediatric Patients: A Network and Proportional Meta-Analyses of Randomized Controlled Trials.

Hsu WT (2026) · Digestive diseases and sciences

7.

Vitamin A, C and/or E Intake During Pregnancy and Offspring Respiratory Health: A Systematic Review and Meta-Analysis.

Murphy VE (2025) · Journal of human nutrition and dietetics : the official journal of the British Dietetic Association

8.

Efficacy of vitamin C supplementation during pregnancy in the prevention of preterm birth: a systematic review and meta-analysis.

Pereira AGA (2025) · Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia

9.

Unlocking the Vitamin Puzzle: Investigating Levels in People With Alzheimer's Disease Versus Healthy Controls Through Systematic Review and Network Meta-Analysis.

Marwaha S (2025) · Journal of human nutrition and dietetics : the official journal of the British Dietetic Association

10.

Effects of Vitamin C and/or E Supplementation on Glycemic Control and Cardiovascular Risk Factors in Type 2 Diabetes: A Systematic Review and Subgroup Meta-analysis.

Aragón-Vela J (2026) · Nutrition reviews

11.

The relationship between antioxidant vitamins and mental disorders: a meta-analysis.

Pan H (2026) · Food & function

12.

Efficacy of vitamin C in COVID-19 management: a systematic review and meta-analysis.

Zhou S (2025) · BMC infectious diseases · n=19

13.

The effect of co-administration of vitamin E and C supplements on plasma oxidative stress biomarkers and antioxidant capacity: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials with meta-regression.

Moabedi M (2025) · Frontiers in immunology

14.

Intravaginal Vitamin C for the Treatment and Prevention of Bacterial Vaginosis: A Systematic Review and Meta-analysis.

Khaikin Y (2026) · Obstetrics and gynecology

15.

Atrial Fibrillation Recurrence Reduction: What Treatments Work Best Postablation? A Network Meta-Analysis.

Jaroonpipatkul S (2025) · Journal of cardiovascular electrophysiology

16.

Effect of vitamin C supplementation on post-exercise recovery: A systematic review and meta-analysis of randomized double-blind placebo trials.

Candeloro BM (2026) · Clinical nutrition ESPEN

17.

Overall and Progression-Free Survival of Patients With Malignant Neoplasm Following Intravenous Vitamin C: A Systematic Review and Meta-Analysis.

Qu J (2025) · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition

18.

The effect of vitamin C supplementation on blood pressure in adults: an umbrella review of meta-analyses of randomized clinical trials.

Kosari A (2026) · Food & function

19.

Oral vitamin C supplementation decreased low-density lipoprotein in adults on hemodialysis: A systematic review and meta-analysis.

de Oliveira IM (2025) · Nutrition research (New York, N.Y.) · n=549

ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.