ProtocolEngine
OutcomesProtocolsSupplementsHabits
ResearchPricing
Get Started
ProtocolEngine

Evidence-based protocols for every health goal, updated daily.

hello@protocolengine.io

Explore

  • Protocols
  • Supplements
  • Habits
  • Research

Tools

  • Protocol Quiz
  • Evidence Assistant

Company

  • About
  • Methodology
  • Glossary
  • Pricing
  • Newsletter

Legal

  • Privacy Policy
  • Terms of Service
  • Refund & Cancellation
  • Medical Disclaimer
  • Affiliate Disclosure
  • Impressum

ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.

© 2026 ProtocolEngine

Research

0+ papers analyzed · 0+ evidence claims extracted

Not sure where to start?

Take our 2-min quiz for a personalized protocol recommendation.

Take the quiz

Research digests

Evidence updates, new findings, and protocol changes from our research pipeline.

Prenatal Biotin Supplementation Shows Measurable Benefits for Maternal and Fetal Biomarkers

Sep 11, 2026· 2 min read

Vaccine Hesitancy in Nigeria: Communication Strategies Show Promise for Closing Immunization Gaps

Sep 10, 2026· 3 min read

Healthcare's Carbon Footprint Shifts Focus to Pharmaceutical Lifecycle Management

Sep 9, 2026· 3 min read

Family Support Networks as Critical Leverage Point for Emergency Responder Wellness

Sep 8, 2026· 3 min read

Alcohol's Dose-Dependent Risk: New Mechanistic Evidence on Chronic Disease Biomarkers

Sep 7, 2026· 2 min read

Renal Rehabilitation Shows Promise for Hemodialysis Patients Facing Anemia and Functional Decline

Sep 6, 2026· 3 min read

Mobile Health Interventions Show Promise for LGBTQ+ Self-Harm Reduction

Sep 5, 2026· 2 min read

Fluoride Biofilm Strategy Shows Promise for Dental Caries Prevention

Sep 4, 2026· 2 min read

Research updates

Effects of plyometric training on explosive power and swimming performance in adolescent swimmers: a systematic review and meta-analysis with dose-response analysis.

Sep 10, 2026· 4 min read

A systematic review found moderate-to-large positive effect sizes suggesting plyometric training may boost explosive power and sprint performance in adolescent swimmers, particularly near peak growth

Sex, Timing, and Outcomes of Curative-Intent Immunotherapy: A Systematic Review and Meta-Analysis.

Sep 10, 2026· 5 min read

A systematic review of 38 randomized trials found immune checkpoint inhibitors (ICIs) improved survival in curative-intent solid tumor treatment, with no significant sex-based differences in efficacy,

Deimplementation of inappropriate feeding practices in early care and education: a Hybrid Type 3 cluster-randomized trial.

Sep 10, 2026· 4 min read

A cluster-randomized trial protocol tests whether a structured intervention package can eliminate harmful feeding practices in early care settings, where children consume roughly 500 meals per year. T

A Smartphone-Based Ecological Momentary Intervention for Workplace Mental Health: Randomized Controlled Trial.

Sep 9, 2026· 4 min read

A 4-week smartphone app using cognitive behavioral therapy and mood tracking reduced depression, anxiety, and stress scores by 14.5 points in working adults, compared to a 3.3-point increase in contro

Effects of home exercise program on endurance, disability and daily participation in non-specific neck pain.

The weekly evidence digest

Every Tuesday in your inbox. No spam, no hype. Just evidence.

In the meantime

Supplement Tier List

Every supplement ranked by evidence strength

Habits & Practices

Evidence-graded behavioral interventions by category

Protocols

Complete routines combining supplements and habits

Foods

Evidence-graded foods, scored via a nutrition-appropriate weight profile

Dietary patterns

Whole-diet frameworks like Mediterranean, DASH, and MIND

Sep 9, 2026· 4 min read

A 4-week home exercise program improved muscular endurance and disability scores in people with nonspecific neck pain, but did not significantly reduce pain intensity [A tier]. The findings suggest ta

Effects of dietary interventions on gut microbiota and related cardiometabolic changes in pediatric obesity: a systematic review and meta-analysis.

Sep 9, 2026· 5 min read

**TL;DR:** A meta-analysis of 8 pediatric studies found that balanced, calorie-restricted diets increased gut microbiota richness (measured by Chao1 index) in children with overweight or obesity, with

Physiological limits of capillary refill time: a human endotoxemia study.

Sep 8, 2026· 5 min read

Capillary refill time (the classic bedside test where you press a fingertip until it turns white, then time how fast color returns) doesn't behave as expected during acute inflammation. A controlled h

Second-to-Fourth Digit (2D:4D) Ratio as A Risk Factor for Osteoporosis and Osteoarthritis: A Systematic Review.

Sep 8, 2026· 4 min read

Lower second-to-fourth digit ratios (2D:4D), a marker of prenatal testosterone exposure, are associated with increased osteoarthritis risk, particularly in the knee and hand, [A tier]. Evidence for os

Using the OPTIMAL Theory to Optimize Aerodynamics in Respiratory Training for Healthy Adults and Individuals With Parkinson's Disease.

Sep 8, 2026· 5 min read

Applying motivation and attention-focused strategies during a single respiratory training session improved peak expiratory flow in both healthy adults and people with Parkinson's disease, though the s

A Web-Based, Pedometer-Mediated Intervention Increases Amount and Intensity of Physical Activity in COPD: A Randomized Controlled Trial.

Sep 6, 2026· 4 min read

A 12-week web-based intervention combining personalized step goals, real-time feedback via Fitbit, and intensity targets increased daily steps by 1,410 steps and shifted 41% of COPD participants from

Functional outcomes following psychotherapy for elevated suicide risk: Secondary analysis of a randomized controlled trial.

Sep 6, 2026· 5 min read

Two evidence-based psychotherapies for active suicide risk produced clinically meaningful improvements in pain, social functioning, and daily activities over 12 months, with gains appearing primarily

Designing Social Media Health Warnings for Teenagers and Young Adults: A Randomized Clinical Trial.

Sep 6, 2026· 5 min read

A randomized trial of 1,012 teenagers and young adults found that health warnings displayed on mock social media platforms increased perceived awareness of social media harms and perceived discouragem