Not recommended
Human studies show no meaningful benefit, potential harm, or the risks outweigh any possible upside. Better alternatives exist.
Also known as: lithium aspartate, low-dose lithium, lithium supplement, microdose lithium
Latest evidence update: 2026-04-01
Strongest in Consistency (35). Held back by Sample size (5).
Limited to weak study designs or thin reporting.
Few independent replications; results not yet robust.
Small combined sample; treat as preliminary.
Mixed direction across studies.
Mostly pre-2020 research; updates may be needed.
No quantified outcomes yet. Once the corpus has studies with measurable endpoints, you will see per-outcome magnitude here.
Recommended: 5-20mg daily (elemental lithium)
ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.
May help slow cognitive decline and improve mental function in mild cognitive impairment and Alzheimer's disease compared to newer drug treatments
Helps prevent relapse in bipolar disorder, especially when combined with other mood stabilizers
Reduces suicidal thoughts and self-harm behaviors in people with depression and bipolar disorder
May improve hand function recovery after stroke, with some patients regaining significant grip strength
Causes increased thirst, increased urination, and diarrhea more frequently than some alternative mood stabilizers