ProtocolEngine.io

Vitamin D3

Also known as: cholecalciferol, vitamin d, d3

SStrong Evidence199 studies referenced

Common dosage

2000-5000 IU daily

Category

vitamin

Description

Essential fat-soluble vitamin that regulates calcium absorption, immune function, and mood. Most people in northern latitudes are deficient.

Safety & interactions

Take with fat for absorption. Test blood levels annually. Pair with K2 to direct calcium to bones.
Check all interactions →

Studies on Vitamin D3 (199)

1.

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis

Martineau AR, et al. (2017) · BMJ · n=11,321

Meta-analysisPubMedDOI
2.

Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease

Manson JE, et al. (2019) · N Engl J Med · n=25,871

3.

Effect of Vitamin D Supplementation on Depressive Symptoms: A Systematic Review and Meta-analysis

Cheng YC, et al. (2020) · JAMA Netw Open · n=7,534

Meta-analysisPubMedDOI
4.

Vitamin D Effects on Musculoskeletal Health, Immunity, Autoimmunity, Cardiovascular Disease, Cancer

Charoenngam N, et al. (2020) · Int J Mol Sci

ReviewPubMedDOI
5.

Childhood malnutrition, rickets, and anemia: a systematic review and meta-analysis on global prevalence, determinants, and public health implications.

Tan Y (2026) · Frontiers in public health

6.

Does Vitamin D₃ Supplementation Improve Exercise Tolerance of D₃ Deficient Chronic Obstructive Lung Disease Patients? - A Randomized Controlled Trial.

Hassan S (2026) · Mymensingh medical journal : MMJ · n=20

7.

Higher Prevalence of Inadequate Vitamin D Intake in Toddlers Not Consuming a Vitamin D Supplement in Vancouver, Canada.

Wiedeman AM (2026) · The Journal of nutrition

8.

Comparative Efficacy and Safety of Intralesional MMR Vaccine and Vitamin D3 in Managing Nongenital Warts: A Systematic Review and Meta-Analysis.

Balach R (2026) · Journal of cosmetic dermatology

9.

Baduanjin Exercise, With or Without Vitamin D, Outperforms Vitamin D Alone in Reducing Frailty Among Institutionalized Older Adults: A Cluster-Based Randomized Controlled Trial.

Gao J (2025) · Nutrients

10.

Vitamin D Supplementation Adjunct to Home-Based Electrical Stimulation Exercise Program Versus Passive Movement Training in Chronic SCI: Individual Results From Trial Under Accrual.

Ifon DE (2025) · Topics in spinal cord injury rehabilitation

11.

Association between prenatal vitamin D supplementation and respiratory diseases in children: a systematic review and meta-analysis.

Shen J (2025) · BMC pediatrics

12.

Vitamin D supplementation and cardiovascular disease events: a systematic review and pooled meta-analysis of randomized clinical trials.

Qudah T (2026) · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · n=379

13.

The effects of Oligo-Fucoidan on muscle function in community-dwelling older adults: A double-blind, randomized, placebo-controlled trial.

Chang YC (2026) · Archives of gerontology and geriatrics

14.

Effectiveness of vitamin D supplementation in managing urinary incontinence and overactive bladder: a systematic review and meta-analysis.

Alshahrani ST (2025) · Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

15.

Impact of vitamin D supplementation on post-stroke rehabilitation outcomes: A systematic review and meta-analysis.

Murbawani EA (2025) · Narra J · n=123

16.

Effect of prenatal high-dose vitamin D on childhood atopic dermatitis is modified by maternal cotinine metabolome: A secondary analysis of a randomized clinical trial.

Brustad N (2026) · Journal of the American Academy of Dermatology

17.

Vitamin D supplementation in pregnant or breastfeeding women or young children for preventing asthma.

Patchen BK (2025) · The Cochrane database of systematic reviews

18.

Effect of vitamin D supplementation for major adverse cardiovascular events: a meta-analysis based on randomised controlled trials.

Cheng X (2025) · The British journal of nutrition

19.

Role of Vitamin D Supplementation in Chronic Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Martinekova P (2025) · Nutrition reviews

20.

Neuroprotective role of high dose Vitamin D supplementation in multiple sclerosis: Sub-analysis of the EVIDIMS trial.

Gomez-Figueroa E (2025) · Multiple sclerosis and related disorders

21.

Effects of vitamin D3, omega-3s, and a simple home exercise program on incident vertebral fractures: the DO-HEALTH randomized controlled trial.

Kistler-Fischbacher M (2025) · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · n=1,488

22.

Intralesional injection of vitamin D3, platelet rich plasma versus their combination in treatment of keloid: a clinical, radiological and immunohistochemical study.

Elwan NM (2025) · Archives of dermatological research

23.

Preoperative Vitamin D Supplementation to Reduce Hypocalcemia Following Total Thyroidectomy: Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Canali L (2025) · Head & neck

24.

Vitamin D supplementation vs. placebo and incident type 2 diabetes in an ancillary study of the randomized Vitamin D and Omega-3 Trial.

Tobias DK (2025) · Nature communications · n=22,220

25.

The effect of vitamin D supplementation on cancer incidence in the randomised controlled D-Health Trial: Implications for policy and practice.

Neale RE (2025) · The Journal of steroid biochemistry and molecular biology · n=21,315

26.

The efficacy of Sarcomeal® oral supplementation plus vitamin D3 on muscle parameters, metabolic factors, and quality of life in diabetic sarcopenia: a randomized controlled clinical trial.

Abdi Dezfouli R (2025) · Aging clinical and experimental research

27.

Therapeutic efficacy of zoledronic acid combined with calcium and calcitriol in the treatment of senile osteoporosis in elderly patients.

Zhang Y (2025) · Inflammopharmacology

28.

Maternal supplementation of vitamin B12 in predominantly vegetarian pregnant women improves their vitamin B12 status and the neurodevelopment of their infants: the MATCOBIND multicentric double-blind randomised control trial.

Nagpal J (2026) · BMJ paediatrics open

29.

Calcium and vitamin D reduce hypoparathyroidism and hospital stay after thyroidectomy: A randomized controlled trial.

Gkanis V (2026) · Surgery

30.

A meta-analysis of the effects of vitamin D supplementation on endocrine metabolic and inflammatory markers in patients with polycystic ovarian syndrome.

Wu B (2026) · Medicine

31.

Is Vitamin D Fortification of Dairy Products Effective for Improving Vitamin D Status? A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Wong CL (2025) · Nutrients · n=4,965

32.

Vitamin supplementation in the treatment of optic neuritis: A systematic review and meta-analysis.

Gaffney PJ (2025) · Multiple sclerosis and related disorders

33.

Effect of vitamin D and E supplementation on pain relief and premenstrual symptoms in primary dysmenorrhea: a randomized controlled trial.

Hosseini MS (2025) · BMC women's health

34.

Effects of dietary supplements on bone turnover markers in women after menopause: a network meta-analysis.

Wei Y (2025) · PeerJ

35.

Intralesional Injection of Vitamin D3 for Treatment of Cutaneous Warts: A Randomized, Double-Blind, Placebo-Controlled Trial.

Merry SP (2025) · Journal of primary care & community health

36.

Impact of Vitamin D3 Supplementation on Androgens and Semen Parameters in Infertile Men: A Systematic Review and Meta-Analysis Based on Prospective Randomised Controlled Trials.

Jiao Y (2025) · Archivos espanoles de urologia

37.

Inappropriate vitamin D supplementation among multimorbid older patients: a multicountry analysis.

Moutzouri E (2025) · BMC geriatrics

38.

The effect of vitamin supplementation on neurodevelopmental and clinical outcomes in very low birth weight and very preterm infants: A systematic review and meta-analysis.

Bronnert A (2025) · PloS one

39.

Increase in calcidiol level is associated with improved sternal bone healing after cardiac surgery with sternotomy-REINFORCE-D trial results.

Černý D (2025) · Trials

40.

Characterizing gut microbial dysbiosis and exploring the effect of prebiotic fiber supplementation in patients with COPD.

van Iersel LEJ (2025) · European journal of nutrition

41.

Effects of probiotic and vitamin D co-supplementation on migraine index, quality of life, and oxidative stress in adults with migraine headache: a randomized triple-blinded clinical trial.

Tirani SA (2025) · European journal of nutrition

42.

The impact of vitamin D supplementation on glycemic control and lipid metabolism in polycystic ovary syndrome: a systematic review of randomized controlled trials.

Yu M (2025) · BMC endocrine disorders

43.

The Effect of Prebiotics and Probiotics (Synbiotics) on Weight Loss and Biochemical Parameters in Obese Individuals.

Son NE (2025) · Journal of medicinal food · n=110

44.

A Bayesian analysis of the VITAL trial: effects of ω-3 fatty acid supplementation on cardiovascular events.

Hamaya R (2025) · The American journal of clinical nutrition

45.

Vitamin D supplementation during pregnancy and offspring bone microarchitecture: A post hoc analysis of the MAVIDOS randomised controlled trial.

Maden C (2026) · Bone

46.

The effects of marine fatty acid omega-3 supplements on incident fractures and bone mineral density in generally healthy adults.

LeBoff MS (2026) · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

47.

Effect of Vitamin D Supplementation on Metabolic Parameters in Patients with Metabolic-Associated Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Yu B (2026) · The Journal of nutrition

48.

Kinetics and concentrations of circulating 25-hydroxyvitamin D using different vitamin D repletion regimens.

Babalyan V (2026) · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

49.

Vitamin D supplementation has no effect on bone mineral density in individuals with chronic spinal cord injury - results from a randomized controlled trial.

Hertig-Godeschalk A (2026) · Spinal cord

50.

A randomized control trial comparing Falls Reduction for Elderly Emergency Department (FREED) interventions and usual care.

Sri-On J (2025) · BMC emergency medicine

51.

Additive renoprotective effects of oral calcitriol on patients with IgA nephropathy receiving RAS blockers.

Joo YS (2026) · Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

52.

Effect of vitamin D supplementation during pregnancy and lactation on the development of infants born to Tanzanian women living with HIV: a secondary analysis of a randomised controlled trial.

Shobanke T (2025) · BMJ open

53.

Effectiveness of Vitamin D Supplementation on Biochemical, Clinical, and Inflammatory Parameters in Patients with Different Types of Diabetes: A Systematic Review and Meta-Analysis.

Bruna-Mejías A (2025) · Nutrients

54.

A Systematic Review and Meta-Analysis of the Effects of Vitamin D on Systemic Lupus Erythematosus.

El Kababi S (2025) · Nutrients · n=12

55.

Global prevalence of vitamin D deficiency among patients with knee osteoarthritis: A systematic review and meta-analysis.

Iqhrammullah M (2026) · Nutrition and health · n=4,248

56.

Effects of weekly cholecalciferol supplementation of lactating mothers on vitamin D status, and infant growth and gross motor development: a randomized controlled trial in rural Ethiopia.

Girma M (2025) · The American journal of clinical nutrition

57.

Impact of body composition on vitamin D requirements in healthy adults with vitamin D deficiency.

Dai D (2025) · Frontiers in endocrinology

58.

Effects of Oral Vitamin D Supplementation on Vitamin D Levels and Glycemic Parameters in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Network Meta-Analysis.

Zhang XJ (2025) · Biomedical and environmental sciences : BES

59.

Pregnancy vitamin D supplementation and bone mineral density of the mother: a post hoc analysis of the MAVIDOS randomised placebo-controlled trial.

Moon RJ (2025) · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

60.

Impact of Vitamin D Supplementation on Cognition in Adults With Mild to Moderate Vitamin D Deficiency: Outcomes From the VitaMIND Randomized Controlled Trial.

Corbett A (2025) · Journal of the American Medical Directors Association

61.

Intralesional measles, mumps, and rubella vaccine versus vitamin D for treatment of warts: A randomised clinical trial.

Sallam M (2026) · Indian journal of dermatology, venereology and leprology · n=56

62.

Concurrent effects of high-intensity interval training and vitamin D supplementation on bone metabolism among women diagnosed with osteoporosis: a randomized controlled trial.

Alghadir AH (2025) · BMC musculoskeletal disorders

63.

Does Vitamin D₃ Supplementation Improve Cardiac Autonomic Nerve Function in Vitamin D₃ Deficient Asthma COPD Overlap (ACO) Patients? A Randomized Clinical Trial.

Yesmin SM (2025) · Mymensingh medical journal : MMJ

64.

Efficacy of high-dose vs. low-dose vitamin D₃ supplementation in children with chronic tic disorders: a randomized controlled trial.

Mohamed ZA (2025) · Nutrition journal

65.

Treatment response variations to a single large bolus of enteral cholecalciferol in vitamin D deficient critically Ill children: Metabolomic insights for precision nutrition.

Helmeczi E (2025) · The Journal of steroid biochemistry and molecular biology

66.

Vitamin D Status and Sepsis Outcomes: A PRISMA-Compliant Umbrella Review and Meta-Analysis.

Castro-Luna G (2026) · Nutrients

67.

Non-Fat Fermented Milk Enhanced the Bioavailability of Fat-Soluble Vitamins in Humans: A Crossover Study.

Morifuji M (2026) · Journal of nutritional science and vitaminology

68.

Effect of Vitamin D Supplementation on Cardiometabolic Outcomes in Older Australian Adults-Results from the Randomized Controlled D-Health Trial.

Duarte Romero BL (2026) · Nutrients · n=21,315

69.

Dietary Supplement Interventions and Sleep Quality Improvement: A Systematic Review and Meta-Analysis.

Mei M (2025) · Nutrients

70.

Effects of combined nutritional supplementation and exercise on proxy measures of muscle mass, strength, and function in older adults with sarcopenia: a 12-week multicentre RCT.

Sun J (2025) · Nutrition journal

71.

Vitamin D Deficiency and Risk of Surgical Site Infections: A Systematic Review and Meta-Analysis.

Farsakoury R (2026) · Surgical infections

72.

Evaluation of the efficacy of vitamin D combined with aspirin and immunoglobulin in treating children with the acute Kawasaki disease.

Cheng Y (2025) · Pakistan journal of pharmaceutical sciences · n=60

73.

Effect of vitamin D on postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting: a systematic review and meta-analysis.

Nisa F (2026) · Minerva cardiology and angiology

74.

Evaluating Protein Liquid Supplementation for Enhanced Protein Intake and Adherence at Short-Term After Metabolic and Bariatric Surgery: A Pilot Randomized Controlled Trial.

Alonso L (2025) · Obesity surgery

75.

Effects of vitamin and multiple micronutrient supplementation for pregnant and/or lactating women on maternal and infant nutritional status in low- and middle-income countries: a systematic review and meta-analysis.

Shinde S (2025) · Advances in nutrition (Bethesda, Md.)

76.

Timing optimization of teriparatide dosing for postmenopausal osteoporosis: a randomized controlled trial.

Wang H (2025) · Journal of orthopaedic surgery and research

77.

Vitamin D supplementation for tuberculosis prevention: A meta-analysis.

Liu S (2025) · Biomolecules & biomedicine · n=15,677

78.

Investigating the efficacy of calcipotriol-acitretin combination therapy versus monotherapy protocols in psoriasis and its effect on serum inflammatory factors: a systematic review and meta-analysis.

Wang H (2025) · European journal of medical research

79.

Extended-Release Calcifediol Normalized 1,25-Dihydroxyvitamin D and Prevented Progression of Secondary Hyperparathyroidism in Hemodialysis Patients in a Pilot Randomized Clinical Trial.

Bishop CW (2026) · American journal of nephrology

80.

Exercise without Weight Loss Prevents Seasonal Decline in Vitamin D Metabolites: The VitaDEx Randomized Controlled Trial.

Perkin OJ (2025) · Advanced science (Weinheim, Baden-Wurttemberg, Germany)

81.

The Effect of Vitamin D3 Supplementation on the Incidence of Diagnosed Dementia Among Healthy Older Adults-The Finnish Vitamin D Trial.

Lönnroos E (2025) · The journals of gerontology. Series A, Biological sciences and medical sciences

82.

The effect of 12-weeks Nutritional supplementation on Nutritional Intake and Status among Indonesian Older Outpatients with Malnutrition Risk, the Prolansia study: a randomized controlled trial.

Dewiasty E (2025) · The journal of nutrition, health & aging

83.

Calcitriol supplementation after kidney transplantation: results of a double-blinded, randomized, placebo-controlled trial.

Khairallah P (2025) · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · n=67

84.

Effects of different vitamin D supplements on body fat distribution and glucolipid metabolism in patients with obesity-associated metabolic syndrome: A meta-analysis.

Huang Q (2026) · Medicine

85.

The impact of vitamin D supplementation on sudden sensorineural hearing loss in vitamin D deficient patients: A double-blind, placebo-controlled trial: A pilot study.

Tavakoli B (2026) · American journal of otolaryngology

86.

Effects of Combined Exercise and Calcium/Vitamin D Supplementation on Bone Mineral Density in Postmenopausal Women: A Systematic Review and Meta-Analysis.

Bai J (2025) · Nutrients

87.

Effects of Resistance Training Combined with Vitamin D Supplementation on Health-Related Variables in the Elderly: Muscle Strength, Body Composition, and Inflammatory Status.

Rosa LCRD (2025) · International journal of environmental research and public health · n=12

88.

Topical calcipotriol versus liquid nitrogen spray in the treatment of palmoplantar warts: An observational study.

Nguyen NDK (2025) · The Journal of international medical research

89.

The Nutritional Challenges Following Revisional Bariatric Surgery After Sleeve Gastrectomy: A Systematic Review and Meta Analysis.

El-Masry H (2025) · Obesity surgery

90.

Does Vitamin D Supplementation Impact Fibromyalgia-Related Pain? A Systematic Review and Meta-Analysis.

Ilari S (2025) · Nutrients

91.

Role of vitamin D supplementation in prevention of new onset atrial fibrillation in post-coronary artery bypass graft patients in vitamin D deficient and insufficient populations: a systematic review and meta-analysis.

Lanka N (2025) · BMC cardiovascular disorders

92.

Effects of vitamin D supplements on bone metabolism in kidney transplant recipients: a systematic review and meta-analysis.

Cai P (2025) · Systematic reviews

93.

Effect of daily sunscreen application on vitamin D: findings from the open-label randomized controlled Sun-D Trial.

Tran V (2025) · The British journal of dermatology

94.

High- vs. routine-dose vitamin D3 in severe lupus on pulse methylprednisolone: a randomized, double-blind, placebo-controlled clinical trial.

Aguila LA (2025) · Clinical rheumatology

95.

Impact of high-dose vitamin D supplementation initiated shortly after diagnosis on residual beta cell function and partial remission rates in children with type 1 diabetes.

Nallapu C (2025) · Journal of pediatric endocrinology & metabolism : JPEM

96.

Efficacy of long-term oral nutritional supplementation with dietary counseling on growth, body composition and bone mineralization in children with or at risk for undernutrition: a randomized controlled trial.

Ow MYL (2025) · Nutrition journal

97.

Effects of Vitamin D2 (Ergocalciferol) on Parathyroid Hormone, Calcium, and Phosphorus in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Lai J (2026) · Nutrition reviews

98.

Impact of vitamin D supplementation in the prognosis of patients with SARS-CoV2 pneumonia admitted to the intensive care unit - a randomized controlled trial.

Gonçalves AM (2025) · Frontiers in immunology

99.

Supplementary zinc and vitamin D in management of symptomatic oral lichen planus: a three-arm randomized clinical trial.

Aboushousha A (2025) · BMC oral health

100.

The association of early pregnancy vitamin D and BMI status with composite adverse pregnancy outcomes: an ancillary analysis of the Vitamin D Antenatal Asthma Reduction Trial.

Jung C (2025) · The American journal of clinical nutrition

101.

Vitamin D Supplementation During Neoadjuvant Chemotherapy for Breast Cancer Improves Pathological Complete Response: A Prospective Randomized Clinical Trial.

Özkurt E (2025) · World journal of surgery

102.

Vitamin D supplementation for managing COVID-19 in patients with vitamin D deficiency: a systematic review and meta-analysis of randomised controlled trials.

Zhu L (2025) · BMJ open · n=19

103.

High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial.

Thouvenot E (2025) · JAMA

104.

A Randomized Trial of Vitamin D Supplementation and COVID-19 Clinical Outcomes and Long COVID: The Vitamin D for COVID-19 Trial.

Ganmaa D (2026) · The Journal of nutrition

105.

Routine vs Selective Calcium Supplementation After Total Thyroidectomy: A Randomized Clinical Trial.

Garcia-Lozano C (2026) · JAMA otolaryngology-- head & neck surgery

106.

Effect of vitamin D as Nutrition Supplement on Patients with Prolonged Ventilation due to Ventilator Associated Pneumonia and Sepsis Followed Severe Traumatic Lung Contusion: A Randomized Controlled Trial.

Allam MGIM (2026) · La Clinica terapeutica

107.

Association Between Vitamin D Deficiency and the Risk of Diabetic Retinopathy in Patients With Type 2 Diabetes: A Meta-Analysis.

Yu G (2026) · Molecular genetics & genomic medicine

108.

Can vitamin D supplementation affect cardiometabolic factors in children and adolescence with overweight and obesity? A grade-assessed systematic review and meta-analysis of randomized controlled trials.

Faghfouri AH (2025) · BMC pediatrics

109.

Vitamin D Supplementation and Testosterone Levels in Breast Cancer Survivors.

Minopoli A (2025) · International journal of molecular sciences

110.

Effects of vitamin K2 and D3 supplementation on epicardial adipose tissue and systemic inflammation: A substudy of the AVADEC trial.

Hasific S (2025) · Atherosclerosis

111.

Effects of 12 Weeks of Whole-Body Vibration Training and Vitamin D Supplementation on Bone Density and Muscle Quality in the Aged with Osteosarcopenia: A Randomized Controlled Trial.

Li W (2025) · Gerontology

112.

Randomized trial of activated vitamin D for acute kidney injury prevention in critically ill patients.

Leaf DE (2025) · JCI insight · n=51

113.

Impact of Omega-3 and Vitamin D Supplementation on Bone Turnover Markers in Children with Leukemia: Follow-Up During and After Supplementation.

Barbosa-Cortés L (2025) · Nutrients

114.

Increasing the quantity of topical corticosteroids applied reduces the severity of psoriasis: results from two randomized controlled trials.

Svendsen MT (2025) · Clinical and experimental dermatology

115.

Impact of almond milk fortified with vitamin D3-loaded soy protein nanoparticles on serum 25(OH)D3 concentrations in adults with CKD: a pilot double-blind randomized controlled trial.

Kuo LY (2025) · Journal of nephrology

116.

Serum klotho is inversely associated with girth in older women but is not associated with falls or musculoskeletal measures in either sex.

Dawson-Hughes B (2025) · The journal of nutrition, health & aging

117.

The impacts of vitamin D supplementation on serum levels of thyroid autoantibodies in patients with autoimmune thyroid disease: a meta-analysis.

Luo D (2025) · PeerJ

118.

Effect of supplementation with vitamin D on biochemical markers of iron status and erythropoiesis in older people: BEST-D trial.

Lamikanra AA (2025) · The British journal of nutrition · n=305

119.

Updated Meta-Analysis on Vitamin Supplementation for Chronic Pruritus: Expanding Evidence Beyond Vitamin D.

Kuo WH (2025) · International journal of molecular sciences

120.

The effect of calcitriol and cholecalciferol on inflammatory markers in periprocedural myocardial injury: A randomized controlled trial.

Mahmoudi L (2025) · Medicine

121.

High-dose vitamin D supplementation in pregnancy ameliorates obesity-induced increase in maternal IL-1β level without affecting obesity-induced increase in IL-6 and MCP.

Andersen HH (2025) · The Journal of steroid biochemistry and molecular biology

122.

High-dose vitamin D3 to improve outcomes in the convalescent phase of complicated severe acute malnutrition in Pakistan: a double-blind randomised controlled trial (ViDiSAM).

Saleem J (2025) · Nature communications

123.

Vitamin D supplementation before in vitro fertilisation in women with polycystic ovary syndrome: multicentre, double blind, placebo controlled, randomised clinical trial.

Hu KL (2026) · BMJ (Clinical research ed.)

124.

Effect Modification by Serum Vitamin A Levels on the Association between Vitamin D and Relapse or Death in Patients with Digestive Tract Cancer.

Kohmura T (2026) · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

125.

Vitamin D Deficiency Among Pregnant Women in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.

Aweke MN (2026) · Journal of human nutrition and dietetics : the official journal of the British Dietetic Association

126.

The effect of nutraceutical interventions on reproductive health outcomes in women with polycystic ovary syndrome: A systematic review and meta-analysis.

Çelik ZM (2026) · Diabetes, obesity & metabolism

127.

The effect of early postpartum vitamin d and e supplementation on uterine after pain: a double-blind randomized clinical trial.

HosseiniHaji S (2025) · BMC women's health

128.

Risk factors for osteoporosis in rheumatoid arthritis patients: a meta-analysis.

Fu T (2026) · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

129.

Effects of vitamin D supplementation on metabolic factors, serum omentin-1, and anthropometric indices in middle-aged women with prediabetes: a double-blind randomized controlled trial.

Molani-Gol R (2025) · Nutrition & diabetes

130.

Early life vitamin D and neurocognitive abilities at age 6-8 years: a randomized clinical trial and observational analysis.

Seppälä V (2026) · European child & adolescent psychiatry

131.

Synergistic effects of exercise, cognitive training and vitamin D on gait performance and falls in mild cognitive impairment-secondary outcomes from the SYNERGIC trial.

Pieruccini-Faria F (2025) · Age and ageing

132.

The effect of hormonal contraceptives combined with vitamin D3 supplements on sexual dysfunction in women with polycystic ovary syndrome: a randomized double-blind placebo-controlled trial.

Jahanian Sadatmahalleh S (2025) · Archives of gynecology and obstetrics

133.

The Impact of Vitamin D Supplementation on Fasting Plasma Glucose, Insulin Sensitivity, and Inflammation in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Probosari E (2025) · Nutrients

134.

Vitamin D3 supplementation enhances the effect of aerobic water-based training on physical fitness indices in obese and overweight menopausal women: A randomized controlled trial.

Zaravar F (2025) · Women's health (London, England)

135.

Impact of Probiotic/Synbiotic Supplementation on Post-Bariatric Surgery Anthropometric and Cardiometabolic Outcomes: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Rakab MS (2025) · Nutrients

136.

Anti-resorptive and anabolic therapies improve Falls Risk Assessment Score (FRAS) in postmenopausal women with type 2 diabetes mellitus.

Prasad TN (2025) · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

137.

Role of vitamin D supplementation and vitamin D receptor in drug-resistant epilepsy: A double-blind placebo-controlled trial conducted in India.

Pattnaik SS (2025) · Epilepsia

138.

Assessment of the effect of routine-dose vitamin D3 supplementation in Chinese women of childbearing age with vitamin D insufficiency.

Shan X (2025) · European journal of nutrition

139.

Vitamin D and tibial bone density, geometry, and microarchitecture in male military recruits: an observational study and randomized controlled trial.

O'Leary TJ (2025) · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

140.

Effect of a Multi-Ingredient Post-Workout Dietary Supplement on Body Composition and Muscle Strength - A Randomized Controlled Trial.

Puente-Fernández J (2025) · Journal of dietary supplements

141.

Impact of Vitamin D Injection on Keloids and Hypertrophic Scars.

Hassan AR (2025) · Journal of cosmetic dermatology

142.

Unveiling the benefits of Vitamin D3 with SGLT-2 inhibitors for hypertensive obese obstructive sleep apnea patients.

Loh HH (2025) · Journal of translational medicine

143.

Vitamin D and Bladder Cancer Risk: An Umbrella Review and Second Order Meta-Analysis.

Mancin S (2026) · Cancer medicine

144.

Preoperative Nutrition-Based Interventions in Children Undergoing Cardiac Surgeries-A Systematic Review and Meta-Analysis.

Stróżyk A (2026) · Nutrients · n=40

145.

Effects of High-Dose Vitamin D Supplementation and Physical Exercise on Vitamin D Metabolites in Professional Football Players: A Pilot Study.

Książek A (2026) · Nutrients

146.

The impact of vitamin D supplementation on anti-Müllerian hormone levels: a systematic review and meta-analysis.

Mirzaei P (2025) · BMC endocrine disorders

147.

Investigation of the Effect of Vitamin D Supplementation on Apical Lesion Healing Rate: Prospective, Randomised Clinical Trial.

Maraş E (2026) · International endodontic journal

148.

Modulation of renal inflammation and tubular injury by calcitriol in patients with early diabetic kidney disease: a randomized controlled trial.

Nugroho P (2025) · Annals of medicine

149.

Short-term and long-term effects of vitamin D supplementation for preterm infants: a systematic review and meta-analysis.

Shin SH (2026) · Journal of perinatology : official journal of the California Perinatal Association

150.

Single high-dose vitamin D supplementation impacts ultramarathon-induced changes in serum levels of bone turnover markers: a double-blind randomized controlled trial.

Stankiewicz B (2025) · Journal of the International Society of Sports Nutrition

151.

Interventions for preventing falls in older people in care facilities.

Dyer SM (2025) · The Cochrane database of systematic reviews

152.

Effects of Leucine Supplementation in Older Adults with Sarcopenia: A Meta-Analysis.

Huang C (2025) · Nutrients · n=566

153.

Effect of calcifediol on chronic rhinosinusitis, a randomized clinical trial.

Popko-Zagor M (2025) · Rhinology

154.

Effect of vitamin D3 supplementation starting mid-pregnancy on placental angiogenic factors and terminal villi: a secondary analysis of a randomized controlled trial in Bangladesh.

Subramanian A (2025) · BMC pregnancy and childbirth

155.

Efficacy and safety of calcitriol therapy for reduction of proteinuria in children with chronic kidney disease: an open-label randomized controlled trial.

Meena J (2025) · International urology and nephrology

156.

Improving Vitamin D Status in Preterm Newborns: A Randomized Trial of 800 vs. 400 IU/Day.

Rueang-Amnat N (2025) · Nutrients

157.

Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable Bowel Syndrome Without Constipation: Results from a Double-Blind, Randomized, Placebo-Controlled Trial.

Laterza L (2025) · Nutrients

158.

Effects of vitamin D supplementation on acute respiratory tract infections in 6-8-year-old children: a randomized clinical trial.

Clerico JW (2025) · European journal of nutrition

159.

Effects of Vitamin D3 Treatment on Polycystic Ovary Symptoms: A Prospective Double-Blind Two-Phase Randomized Controlled Clinical Trial.

Tóth BE (2025) · Nutrients

160.

Impact of Cholecalciferol Supplementation on Radiotherapy Outcomes in Advanced Cervical Cancer.

Suardi D (2025) · Medical science monitor : international medical journal of experimental and clinical research · n=123

161.

Impact of Vitamin D3 on Postorthodontic Treatment Stability: A Randomized Controlled Trial.

Kothandaraman T (2024) · The journal of contemporary dental practice

162.

Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 or Vaccination: A Randomized Controlled Trial.

Kodama S (2026) · Nutrients · n=91

163.

Effects of personalized vitamin D3 on inflammation in colorectal cancer patients: a randomized trial.

Gwenzi T (2026) · British journal of cancer

164.

High-dose vitamin D supplementation and prostate cancer progression: a phase II randomised trial in localised prostate cancer cases with intermediate risk of progression (ProsD).

Nair-Shalliker V (2026) · British journal of cancer

165.

Prevalence and risk factors of hypovitaminosis D among patients with diabetes mellitus from India: A systematic review and meta-analysis.

Bhaduri G (2025) · Diabetes & metabolic syndrome

166.

Impact of phytase supplementation on performance and egg quality traits in broiler breeders: A meta-analysis.

Yamawaki RA (2025) · Poultry science

167.

Effectiveness of Combined Vitamin D and Iron Supplementation on Iron Status in Children with Iron Deficiency Anemia: A Randomized Controlled Trial.

Rasyid Ridha N (2025) · The journal of medical investigation : JMI

168.

Vitamin D for Painful Diabetic Neuropathy: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Gilbody A (2025) · Endocrinology, diabetes & metabolism

169.

Comparative study on the efficacy of menadione, zoledronic acid, and calcitriol in combination with PKP for the treatment of osteoporotic vertebral compression fractures in extremely elderly patients.

Yu H (2025) · Medicine

170.

Process evaluation of a randomised controlled trial aimed at improving health behaviours and vitamin D status during pregnancy: Implementation of the SPRING trial.

Proebstl S (2025) · PloS one

171.

Comparative evaluation of the effects of diclofenac sodium and vitamin D supplementation on symptoms in individuals with myofascial pain and vitamin D deficiency: a randomized controlled clinical trial.

Kahraman NH (2025) · BMC oral health

172.

Role of vitamin D as adjuvant therapy on multiple sclerosis: an updated systematic review and meta-analysis of randomized controlled trials.

Serag I (2025) · European journal of medical research

173.

Early Vitamin D Supplementation in Infants Born Extremely Preterm and Fed Human Milk: A Randomized Controlled Trial.

Salas AA (2025) · The Journal of pediatrics

174.

Impact of vitamin D3 supplementation on motor functionality and the immune response in Parkinson's disease patients with vitamin D deficiency.

Li D (2025) · Scientific reports

175.

Relationship between Circulating Vitamin D Concentration and the Maternal Gut Microbiota during Early Pregnancy in Japanese Women: Results of a Pilot Study of Antenatal Vitamin D3 Supplementation.

Kang HS (2025) · Journal of nutritional science and vitaminology

176.

Efficacy of daily 4,000 International Units (IU) versus 6,000 IU of oral vitamin D3 in vitamin D deficient children with overweight and obesity: An open-label randomized controlled trial.

Setia P (2025) · Clinical nutrition ESPEN

177.

Co-administration of vitamin D and N-acetylcysteine to modulate immunosenescence in older adults with vitamin D deficiency: a randomized clinical trial.

Rastgoo S (2025) · Frontiers in immunology

178.

Association Among Vitamin D Receptor Gene Polymorphisms, Metabolic Control, and Inflammatory Markers in Type 2 Diabetes: A Systematic Review and Meta-Analysis.

Santos RKF (2026) · Nutrition reviews

179.

Effect of calcifediol and cholecalciferol on muscle function in postmenopausal women: a randomized controlled trial.

Bischoff-Ferrari HA (2025) · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

180.

Effect of CYP2R1 and GC gene polymorphisms on serum 25(OH)D response to vitamin D3 supplementation in prediabetes.

Ni P (2025) · European journal of clinical nutrition

181.

Effects of vitamin D3, omega-3 fatty acids and a simple home exercise program on change in physical activity among generally healthy and active older adults: The 3-year DO-HEALTH trial.

Hussein K (2025) · The journal of nutrition, health & aging

182.

Plasma vitamin D and cytokines in relation to exercise in patients with fibromyalgia- A 15-week strength training intervention trial.

Samefors M (2026) · Scandinavian journal of pain

183.

A meta-analysis of the literature evaluating the impact of vitamin D on female fertility and ovarian reserve function.

Zhao S (2026) · Revista da Escola de Enfermagem da U S P

184.

Vitamin D supplementation and incidence of major depressive disorder - A randomized clinical trial.

Ahl NM (2026) · Clinical nutrition (Edinburgh, Scotland)

185.

Impact of high-dose vitamin D and calcium carbonate supplementation on bone density in adolescents living with HIV: a randomised, placebo-controlled trial.

Ferrand RA (2026) · The Lancet. Child & adolescent health

186.

Efficacy of Vitamin D3 Supplementation in Elevating Circulating 25(OH)D Concentration in Individuals With Chronic Spinal Cord Injury (VitD-SCI): Evidence From a Randomized, Double-Blind, Placebo-Controlled Trial.

Hertig-Godeschalk A (2025) · Topics in spinal cord injury rehabilitation

187.

Impact of vitamin D supplementation on short- and long-term mortality in sepsis: A systematic review and meta-analysis.

Zhang H (2025) · Respiratory medicine

188.

Clinical efficacy of vitamin D combined with conventional therapy for sudden sensorineural hearing loss in patients with vitamin D deficiency: a randomized controlled trial.

Shen X (2025) · Head & face medicine

189.

Efficacy of two calcifediol supplementation regimens in older adults post-hip fracture surgery. A clinical trial.

Cuadra-Llopart L (2026) · European geriatric medicine

190.

Higher serum vitamin D concentration and supplementation were associated with improved survival outcomes and treatment response in cancer patients receiving immunotherapy: A systematic review and meta-analysis.

Yang Q (2025) · Nutrition research (New York, N.Y.)

191.

The Role of Functional Brain Connectivity in Intervention Success: A Secondary Analysis from the SYNERGIC Trial.

Bray NW (2025) · Medicine and science in sports and exercise

192.

Phosphate concentration is exceptionally high in seminal fluid and is linked with semen quality but not influenced by vitamin D and calcium supplementation.

Toft FB (2025) · European journal of endocrinology

193.

Multimicronutrient and omega-3 fatty acid supplementation reduces low-grade inflammation in older participants: An exploratory study.

Kerlikowsky F (2025) · Nutrition research (New York, N.Y.)

194.

Identification of individuals who benefit from omega-3 fatty acid supplementation to prevent coronary heart disease: a machine-learning analysis of the VITAL.

Hamaya R (2025) · European journal of epidemiology

195.

The interaction of vitamin D supplementation with Omentin-1 gene polymorphism on metabolic biomarkers, omentin-1 levels and anthropometric measures in women with prediabetes: A double-blind randomized controlled trial.

Molani-Gol R (2025) · Diabetes, obesity & metabolism

196.

Vitamin D3 and marine ω-3 fatty acids supplementation and leukocyte telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial.

Zhu H (2025) · The American journal of clinical nutrition

197.

Vitamin supplementation and its effect on incident type 1 diabetes mellitus and islet autoimmunity: a systematic review and meta-analysis.

Low CE (2025) · Frontiers in immunology

198.

Efficacy of a Personalized mHealth App in Improving Micronutrient Supplement Use Among Pregnant Women in Karachi, Pakistan: Parallel-Group Randomized Controlled Trial.

Vadsaria K (2025) · Journal of medical Internet research

199.

Vitamin D Supplementation Improves Pathological Complete Response in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy: A Randomized Clinical Trial.

Omodei MS (2025) · Nutrition and cancer

ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.