Glutathione

Also known as: GSH, liposomal glutathione, reduced glutathione

Confidence

research strength

ASolid confidence73353 studies referenced

Latest evidence update: 2026-06-06

Strongest in Sample size (83). Held back by Recency (54).

Study quality (37%)

Study design (21%)

Risk of bias (16%)

Solid mix of RCTs with some methodological gaps.

Replication (26%)

Cross-study replication (21%)

Precision (5%)

Confirmed across many independent studies with significant findings.

Sample size (16%)

Tens of thousands of participants pooled across studies.

Consistency (11%)

Mostly aligned, with some divergence.

Recency (10%)

Evidence base skews older; field may have moved on.

Effect by outcome

how big the change is

Immune function Skin, hair & nails Longevity & aging

Common dosage

250-500mg daily (liposomal)

Description

The body's master antioxidant. Oral bioavailability is poor — liposomal or NAC (precursor) are better strategies.

Safety & interactions

Liposomal form only for oral use. NAC is often a more cost-effective way to raise glutathione levels.

Check interactions with other supplements→

What the research shows

→

May affect how different areas of the brain communicate with each other in people with Parkinson's disease

emerging evidence1 study:Parkinsonism & related disorders (2026)

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Order Glutathione

Recommended: 250-500mg daily (liposomal)

Protocols featuring Glutathione

Gut Health ResetBBuilding confidence

Questions about Glutathione

Who has been studied for Glutathione?

Who should avoid Glutathione based on the safety notes?

What dose did studies use for Glutathione, and when was it taken?

Referenced studies (353)

ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.