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Omega-3 (EPA/DHA)

Also known as: fish oil, EPA, DHA, omega 3 fatty acids

SStrong Evidence183 studies referenced

Common dosage

2-3g combined EPA/DHA daily

Category

fatty acid

Description

Essential fatty acids with strong evidence for cardiovascular health, inflammation reduction, and cognitive function. EPA is more anti-inflammatory; DHA supports brain structure.

Safety & interactions

Choose triglyceride form over ethyl ester. May thin blood — consult doctor if on blood thinners.
Check all interactions →

Studies on Omega-3 (EPA/DHA) (183)

1.

Marine Omega-3 Supplementation and Cardiovascular Disease: An Updated Meta-Analysis

Hu Y, et al. (2019) · J Am Coll Cardiol · n=127,477

Meta-analysisPubMedDOI
2.

Association of Use of Omega-3 Polyunsaturated Fatty Acids With Changes in Severity of Anxiety Symptoms

Su KP, et al. (2018) · JAMA Netw Open · n=2,240

Meta-analysisPubMedDOI
3.

Omega-3 polyunsaturated fatty acids and depression: a systematic review and meta-analysis

Liao Y, et al. (2019) · J Affect Disord · n=3,400

Meta-analysisPubMedDOI
4.

Comparative Effects of Dietary Protein, Creatine, and Omega-3 Supplementation on Muscle Strength, Endurance, and Recovery in Trained Athletes: A Systematic Review and Network Meta-Analysis.

Wang Z (2026) · Nutrients · n=1,211

5.

Effects of Omega-3 Supplementation on Inflammation and Recovery in Sports: A Meta-Analysis.

Li Z (2026) · FASEB journal : official publication of the Federation of American Societies for Experimental Biology

6.

Maternal 12-HETE is associated with childhood asthma and the responses to prenatal omega-3 supplementation.

Chen L (2026) · Cell reports. Medicine

7.

A Mediterranean lifestyle obesity prevention intervention in preschoolers at risk: MELI-POP Study-a randomized controlled trial.

Larruy-García A (2026) · European journal of pediatrics

8.

Effect of high-docosahexaenoic acid omega-3 supplementation in low-risk pregnant women on maternal and neonatal health outcomes in Southeast Brazil: a randomized clinical trial.

de Sousa TM (2026) · Journal of tropical pediatrics

9.

Forensic Perspective of Unintentional Doping, Cardiovascular Health, and the Role of Nutrition in Competitive Sports.

Šoša I (2026) · Nutrients

10.

Do Adjunctive Therapies with Natural Products Improve Periodontal Clinical Parameters After Non-Surgical Treatment? A Systematic Review and Meta-Analysis.

de Molon RS (2026) · International journal of molecular sciences

11.

Instability of Global Burden of Disease Estimates of Deaths and Disability-Adjusted Life-Years From Major Risk Factors: A Meta-Epidemiological Analysis.

Zavalis EA (2026) · JAMA health forum

12.

Effect of Perioperative Supplementation with Arginine and Omega-3 on Postoperative Complications in Patients Undergoing Gastrointestinal Cancer Surgery: A Pilot Open-Label Randomized Controlled Trial.

Sakhri S (2026) · Nutrients

13.

Effects of 8 Weeks of Resistance Training Combined with a High-Protein Diet and Omega-3 Supplementation on Body Composition, Muscular Performance, and Muscle-Related Biomarkers in Overweight Women.

Radfar B (2026) · Nutrients

14.

Effects of Structured Lipid Supplementation for Eight Weeks on Substrate Utilization During Moderate Intensity Exercise in Healthy Untrained Men.

Wang C (2026) · Nutrients · n=36

15.

Factors associated with adherence to allocated treatment in the ASCEND trial: a mail-based randomised trial of aspirin and of omega-3 fatty acid supplementation in people with diabetes.

Madurasinghe VW (2026) · Trials · n=15,480

16.

Leveraging precision medicine analytics to optimize inflammation reduction and enhance physical function in older adults.

Tharwani SD (2026) · The journals of gerontology. Series A, Biological sciences and medical sciences

17.

Anti-inflammatory effects and safety of omega-3 fatty acids in haemodialysis: A systematic review and meta-analysis.

Blair C (2026) · Clinical nutrition ESPEN

18.

Effect of 21-Day Omega-3 Polyunsaturated Fatty Acid Supplementation on Exercise-Induced Secretory Factors and Inflammation Status in Young Men: A Randomized Double-Blind Trial.

Konert M (2026) · Nutrients · n=12

19.

A network meta-analysis of interventions for anxiety and depression in PCOS.

Tan Z (2026) · PeerJ

20.

Impact of conventional lipid-lowering therapy on circulating levels of proprotein convertase subtilisin/kexin type 9: A systematic review and meta-analysis of randomised controlled trials.

Meng L (2026) · Diabetes, obesity & metabolism · n=1,313

21.

Impact of prenatal omega-3 fatty acids supplementation on cognitive outcomes: A systematic review with meta-analysis.

Musillo C (2026) · Neuroscience and biobehavioral reviews

22.

A randomized safety and feasibility crossover trial of two Mediterranean-ketogenic interventions in individuals with Parkinson's disease.

Tosefsky K (2026) · Journal of Parkinson's disease · n=52

23.

A multicomponent intervention consisting of exercise, proteins and omega-3 supplementation to improve sarcopenia in community-dwelling older adults: Lessons learned from a 5-armed randomized controlled feasibility trial.

Amini N (2026) · The Journal of frailty & aging

24.

Enteral lipid supplements for the prevention and treatment of parenteral nutrition-associated liver disease in infants.

Premkumar MH (2026) · The Cochrane database of systematic reviews

25.

Effects of fish oil supplementation on biomarkers of vascular endothelial function in middle-aged and older adults: a randomized controlled trial.

Quan C (2026) · Food & function · n=240

26.

Marine n-3 fatty acid treatment for carotid plaques in patients with type 2 diabetes.

Zhuang P (2026) · Cardiovascular diabetology

27.

Impact of omega-3 supplementation on lipoprotein-associated phospholipase A2 mass and activity: A systematic review and meta-analysis of randomized controlled trials.

Simental-Mendía LE (2026) · Journal of clinical lipidology

28.

An exploratory, open-label, pilot randomized trial of omega-3 fatty acid supplementation on serum ferritin in university female students: The OMEGA-3 FA study.

Fujibayashi M (2026) · Clinical nutrition ESPEN

29.

Perioperative immunonutrition and outcomes in head and neck cancer surgery - a randomized clinical trial: Effects of perioperative immunonutrition in patients with head and neck cancer.

Başmisirli E (2026) · Medicine

30.

The Role of Omega-3 Polyunsaturated Fatty Acid Supplementation in Postoperative Recovery of Colorectal Cancer: Systematic Review and Meta-Analysis.

Li H (2026) · Nutrients

31.

Associations Between Dietary Intakes of Omega-3 Fatty Acids, Blood Levels, and Pain Interference in People with Migraine: A Path Analysis of Randomized Trial Data.

Park J (2025) · Nutrients · n=182

32.

Omega-3 Fatty Acids Supplementation Improves Pulmonary Function and Clinical Outcomes in Critically Ill Patients: a Meta-Analysis.

Wu MY (2026) · The Journal of nutrition

33.

Proteomic Profile in Retinopathy of Prematurity: A Secondary Analysis of the Mega Donna Mega Randomized Clinical Trial.

Lundgren P (2026) · JAMA ophthalmology

34.

Efficacy and safety of highly purified ethyl icosapentate soft capsules (MND-21) for the treatment of severe hypertriglyceridemia: A 12-week, multi-center, placebo-controlled, randomized, double-blind, phase III clinical trial in China.

Wang Y (2026) · Journal of clinical lipidology

35.

Effects of diacylglycerol-enriched alpha-linolenic acid oil on skin properties in mild skin discomfort: a randomized, double-blind, placebo-controlled study.

Fukagawa S (2026) · Scientific reports

36.

Omega-3 fatty acids and cardiovascular risk-related metabolic markers in diverse populations: a meta-analysis of randomized trials.

Chen C (2026) · Nutrition, metabolism, and cardiovascular diseases : NMCD

37.

Can Omega-3 Fatty Acids Serve as a Preventive Strategy for Age-Related Macular Degeneration? A Systematic Review and Meta-Analysis.

Chen KY (2026) · The Journal of nutrition

38.

Impact of maternal diet on microbiota and health during pregnancy: a systematic review and correlational meta-analysis.

Ventura EF (2026) · The American journal of clinical nutrition

39.

ω-3 Fatty Acids in Pediatric Major Depressive Disorder: A Randomized Clinical Trial.

Berger G (2026) · JAMA network open

40.

Effect of Flaxseed Supplementation on Headache Characteristics and Quality of Life in Patients with Migraine: A Randomized Controlled Trial.

Jafarpour A (2026) · The Journal of nutrition

41.

Effect of Beetroot Extract Supplementation on Serum Fatty Acid Profiles and Oxidative Stress Markers in Chronic Coronary Artery Disease Patients: A Secondary Analysis of a Randomized Controlled Trial.

Mansouri-Baseri A (2025) · BioMed research international

42.

Effects of microalgae supplementation on performance, egg quality, yolk fatty acid levels, and blood parameters in laying hens: a meta-analysis.

Anam MS (2025) · Scientific reports

43.

Pesco-Vegetarian Food Components Promote Colonocyte Ferroptosis in Preclinical Mouse Models and a Randomized Crossover Trial in Healthy Human Adults.

Fan YY (2026) · The Journal of nutrition

44.

Effects of EPA+DHA and Corn Oil Supplementation on PUFA Concentrations across Plasma Lipid Pools and on Downstream Oxylipins: Exploratory Results from a Randomized Controlled Trial in Healthy Humans.

Balakrishnan N (2026) · The Journal of nutrition

45.

The effects of Omega-3 supplementation on stress, anxiety, depression, sleep quality, and everyday memory in individuals with psychological distress: A randomized, double-blind, placebo-controlled trial.

Azhar W (2026) · Journal of affective disorders

46.

Fatty acid composition of isoenergetic meals drives distinct postprandial immunometabolic responses in healthy adults: A randomized crossover pilot study.

Marquez-Paradas E (2026) · The Journal of nutritional biochemistry

47.

[High-dose omega-3 fatty acid supplementation in patients with persistent allergic rhinitis sensitized to perennial allergens: a randomized, placebo-controlled clinical trial].

Armenta-Morales J (2025) · Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)

48.

Postprandial modulation of the surface profile and cellular origin of circulating extracellular vesicles by dietary fatty acid composition: A randomized crossover pilot study in young healthy adults.

Marquez-Paradas E (2026) · Clinical nutrition (Edinburgh, Scotland)

49.

Cardioprotective mechanism of ω-3 fatty acid icosapent ethyl (IPE) in cardiomyocytes: role in high glucose and shear stress-induced mechano-transduction dysregulation.

Pesapane A (2025) · Cardiovascular diabetology

50.

Marine ω-3 PUFA Supplementation Enhances FFAR4 Activation and Reduces Inflammatory Markers in PBMC of Subjects with Obesity: A Randomized Controlled Trial (EPICO).

Reyes-Pérez SD (2025) · Nutrients

51.

Fatty Acid Biomarkers and Incidence of Type 2 diabetes: A Systematic Review and Dose-Response Meta-analysis of Prospective Observational Studies.

Schaefer E (2026) · Advances in nutrition (Bethesda, Md.)

52.

Changes in erythrocyte fatty acid profile after 12 weeks of omega-3 fatty acid (EPA+DHA) supplementation and endurance training in amateur runners.

Tomczyk M (2026) · Prostaglandins, leukotrienes, and essential fatty acids

53.

Do the effects of krill oil supplementation on skeletal muscle function and size in older adults differ by sex, age or BMI: A secondary analysis of a randomised controlled trial.

Hayman O (2026) · The journal of nutrition, health & aging · n=45

54.

Assessing a Panel of Biomarkers in Plasma Reflecting Dietary Intakes: Data From a Large Randomized Controlled Trial.

Shahin A (2026) · Molecular nutrition & food research · n=245

55.

Association between lid margin collarettes and dry eye disease severity in the Dry Eye Assessment and Management (DREAM) study.

Azar AE (2026) · Eye (London, England)

56.

Comparison of EPA and DHA&EPA on body weight, BMI, and lean body mass in cancer patients: a network meta-analysis.

Lu H (2025) · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

57.

Associations between fatty acids providing support for n-3 and n-6 pathways are strongest in pregnant Indian vegetarians compared with pregnant Australian omnivores.

Mugford M (2025) · Prostaglandins, leukotrienes, and essential fatty acids · n=332

58.

Eicosapentaenoic acid decreases inflammation and improves glucose homeostasis in patients with burns: a randomized clinical trial.

Mousavi MA (2025) · Scientific reports

59.

Effects of Acute Fish Oil Supplementation on Muscle Function and Soreness After Eccentric Contraction-Induced Muscle Damage.

Lee SR (2025) · Nutrients

60.

Effect of n-3 polyunsaturated fatty acids on the treatment of schizophrenia: an updated systematic review and meta-analysis.

Lin CY (2025) · BMC psychiatry

61.

Developmental outcomes after soybean oil vs mixed-oil intravenous lipid emulsions in neonates: A secondary analysis of a clinical trial.

Huff KA (2026) · JPEN. Journal of parenteral and enteral nutrition

62.

Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis.

Lok CE (2026) · The New England journal of medicine

63.

The Impact of Antioxidant Adjuncts on Periodontal Health in Type 2 Diabetes Patients: A Meta-Analysis.

Abdulla SA (2025) · Clinical and experimental dental research

64.

Marine-Based Omega-3 Fatty Acids and Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Basirat A (2025) · Nutrients

65.

Comparative Bioavailability of DHA and EPA from Microalgal and Fish Oil in Adults.

Bailey E (2025) · International journal of molecular sciences

66.

The anti-inflammatory effects of three different dietary supplement interventions.

Vijay A (2025) · Journal of translational medicine

67.

Influence of Fish Consumption and ω-3 Supplementation on the ω-3 Index of Young Adults: A 2 × 2 Factorial Randomized Controlled Trial (YouFish Study).

McMullan JE (2025) · The Journal of nutrition

68.

n - 3 polyunsaturated fatty acids mediate hyodeoxycholic acid-FXR signaling to ameliorate metabolic dysfunction-associated fatty liver disease.

Wang Y (2026) · The Journal of nutritional biochemistry

69.

Docosahexaenoic acid supplementation in pregnancy and early lactation: Impacts on breast milk docosahexaenoic acid and Maternal-Infant gut microbiota - A randomized controlled trial.

He T (2025) · Clinical nutrition (Edinburgh, Scotland)

70.

Efficacy of probiotic co-supplementation with omega-3 PUFAs on pancreatic beta-cell function in type 2 diabetes.

Savytska M (2025) · Scientific reports · n=45

71.

Omega-3 Polyunsaturated Fatty Acids and Cognitive Decline in Adults with Non-Dementia or Mild Cognitive Impairment: An Overview of Systematic Reviews.

Barros MI (2025) · Nutrients

72.

Synbiotic Supplementation with Probiotics and Omega-3 Fatty Acids Enhances Upper-Body Muscle Strength in Elite Swimmers: Evidence for Gut-Muscle Axis Modulation During Race-Pace Training.

Imanian B (2025) · Nutrients

73.

Omega-3 fatty acid supplementation for distal symmetrical peripheral neuropathy in adults with diabetes mellitus.

Britten-Jones AC (2025) · The Cochrane database of systematic reviews

74.

Association between omega-3 fatty acid intake and risk of diabetic retinopathy: A systematic review and meta-analysis.

Chen KY (2025) · The journal of nutrition, health & aging

75.

Effects of omega-3 fatty acids on hyper-inflammatory response and clinical outcomes in critically ill patients: a meta-analysis.

Liu T (2026) · Intensive & critical care nursing

76.

The effectiveness of intervention with omega-3 fatty acids, eicosapentaenoic and docosahexenoic acid in peripheral arterial disease: a systematic review and meta-analysis.

Dao TK (2026) · Nutrition, metabolism, and cardiovascular diseases : NMCD

77.

Randomised crossover controlled trial of dietary interventions for glycaemic control when body weight is kept stable.

Fontes-Villalba M (2025) · Journal of nutritional science · n=14

78.

Omega-3 fatty acid supplementation in solid organ transplant recipients: A systematic review and meta-analysis of randomized controlled trials.

Samankan S (2025) · Clinical nutrition ESPEN

79.

Effects of spirulina (Arthrospira) platensis supplementation on inflammation, physical and mental quality of life, and anthropometric measures in patients with relapsing-remitting multiple sclerosis (RRMS): a triple-blinded, randomized, placebo-controlled trial.

Karimi S (2025) · Nutrition journal

80.

Anti-Inflammatory Diet and Probiotic Supplementation as Strategies to Modulate Immune Dysregulation in Autism Spectrum Disorder.

Naranjo-Galvis CA (2025) · Nutrients

81.

The Efficacy of Daily Salmon Oil for Adult Type 2 Asthma: An Exploratory Randomized Double-Blind Trial.

Mølsæter K (2025) · Marine drugs · n=66

82.

Association between non-adherence to fish oil or placebo as a risk factor of transition to psychosis in ultra-high-risk individuals in the NEURAPRO study.

Schlögelhofer M (2025) · The Australian and New Zealand journal of psychiatry

83.

Effects of docosahexaenoic acid supplementation on aggressive behavior among people with dementia: Secondary data analysis of a randomized clinical trial.

Perales-Puchalt J (2025) · Alzheimer disease and associated disorders

84.

Dietary fat is associated with increased inflammatory bowel disease onset risk: a systematic review and dose-response meta-analysis.

Zhang S (2025) · International journal of surgery (London, England)

85.

A systematic review and dose response meta analysis of Omega 3 supplementation on cognitive function.

Shahinfar H (2025) · Scientific reports

86.

Connecting plant, animal, and human health using untargeted metabolomics.

Fleming A (2025) · Journal of animal science

87.

Myokine Circulating Levels in Postmenopausal Women with Overweight or Obesity: Effects of Resistance Training and/or DHA-Rich n-3 PUFA Supplementation.

Martínez-Gayo A (2025) · Nutrients

88.

Effects of purified eicosapentaenoic acid versus mixed eicosapentaenoic/docosahexaenoic acid pharmacotherapies on coronary plaque volume: network meta-analysis of prospective coronary imaging trials.

Sheppard JP (2025) · Acta cardiologica

89.

Effects of Prenatal DHA Dose on Infant Visual Attention.

Colombo J (2025) · Developmental psychobiology

90.

Maternal phthalate exposure, gestational length, and preterm birth risk: a prospective cohort study nested within a randomised trial.

Best KP (2025) · BMC pregnancy and childbirth

91.

Genetic evidence reveals phosphatidylcholine as a mediator in the causal relationship between omega-3 and multiple myeloma risk.

Li J (2025) · Scientific reports

92.

Gut microbial community and host intestinal gene expression with combined fish oil and soluble corn fiber compared with corn oil and maltodextrin: A randomized crossover trial in healthy older individuals.

Moosavi D (2025) · The American journal of clinical nutrition

93.

The Effects of α-Linolenic Acid Intake on Skin and Blood Vessel Health and Subjective Fatigue in Middle-Aged Japanese Females: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparative Trial.

Ando N (2025) · The Journal of nutrition

94.

Effects of maternal allergy and supplementation with ω-3 fatty acid and probiotic on human milk oligosaccharides.

Al-Kaabawi A (2025) · Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

95.

Impact of fatty diets on blood pressure: A systematic review and meta-analysis.

Zang T (2025) · Asia Pacific journal of clinical nutrition

96.

Perioperative Immunonutrition in Gastrointestinal Oncology: A Comprehensive Umbrella Review and Meta-Analysis on Behalf of TROGSS-The Robotic Global Surgical Society.

Goyal A (2025) · Nutrients

97.

Synergistic Effects of Probiotic and Omega-3 Supplementation with Ultra-Short Race Pace Training on Sprint Swimming Performance.

Maymandinejad I (2025) · Nutrients · n=10

98.

Effects of immunonutrition on serum albumin, IL-6, and TNF-α levels in patients with COVID-19: a randomized controlled double-blind clinical trial.

Lopes LC (2026) · Nutricion hospitalaria · n=70

99.

Edible Algae Reduce Blood Pressure in Humans: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Casas-Agustench P (2025) · Journal of human nutrition and dietetics : the official journal of the British Dietetic Association

100.

Fatty acid dietary intakes and blood concentrations in relation to hip fracture risk in adults: a systematic review and meta-analysis of prospective cohort studies.

Niazi S (2025) · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · n=382,094

101.

2-Hydroxybenzylamine for Treatment of Atrial Fibrillation: A First-in-Human Clinical Pilot Trial.

Yoneda ZT (2025) · Circulation. Arrhythmia and electrophysiology

102.

Consuming grass finished lamb improves blood plasma ω-3 fatty acid response among healthy consumers.

Perkins LS (2025) · European journal of nutrition

103.

Plasma chylomicron-rich lipidomic and fatty acid profile following a meat or analog meal in healthy males: A randomized controlled trial.

Pham T (2025) · The American journal of clinical nutrition

104.

Serum Alpha-Linolenic Acid and Long-Term Multiple Sclerosis Activity and Progression.

Cortese M (2025) · Neurology

105.

Benefits of Krill Oil Supplementation During Alternate-Day Fasting in Adults With Overweight and Obesity: A Randomized Trial.

Alblaji M (2025) · Obesity (Silver Spring, Md.)

106.

The effects of docosahexaenoic acid (DHA) on plasma cytokines, oxylipins, and tumor-infiltrating lymphocytes from women with breast cancer undergoing neoadjuvant chemotherapy in the DHA-WIN trial.

Munhoz J (2025) · The Journal of nutritional biochemistry · n=23

107.

The Effects of Omega-3 Supplementation Combined with Strength Training on Neuro-Biomarkers, Inflammatory and Antioxidant Responses, and the Lipid Profile in Physically Healthy Adults.

Okut S (2025) · Nutrients

108.

Treatment of delirium in intensive care patients with sepsis using daily intravenous infusions with omega-3 fatty acids.

Wang DQ (2025) · International journal of clinical pharmacology and therapeutics

109.

The efficacy of adjunctive Garcinia mangostana Linn. (mangosteen) pericarp extract for bipolar depression: 24-week randomised controlled trial.

Dean OM (2025) · The British journal of psychiatry : the journal of mental science

110.

Effect of lipid-lowering therapies on lipoprotein(a) levels: a comprehensive meta-analysis of randomized controlled trials.

Xie S (2025) · Atherosclerosis

111.

The effectiveness of nutritional supplements in improving polycystic ovary syndrome in women: a systematic review and network meta-analysis.

Zhao G (2025) · Reproductive biology and endocrinology : RB&E

112.

Differential cardiovascular impact of ω-3 fatty acid in patients at high cardiovascular risk in Asians versus non-Asians: Sub-analysis of the strength randomized clinical trial.

Wang TKM (2025) · Atherosclerosis

113.

Effects of fish oil intervention on type 2 diabetes early risk novel biomarkers in healthy middle-aged and elderly adults: a double-blind randomized controlled trial.

Nian Z (2025) · Food & function · n=240

114.

Dose-dependent effects of omega-3 polyunsaturated fatty acids on C-reactive protein concentrations in cardiometabolic disorders: a dose-response meta-analysis of randomized clinical trials.

Amlashi MA (2025) · Inflammopharmacology

115.

The effect of fish oil versus krill oil intervention on clinical symptoms and cardiometabolic risk factors in patients with major depressive disorder: A randomized placebo-controlled double-blind trial.

Açik M (2025) · Journal of affective disorders

116.

Medical Nutrition Therapy (MNT) Evidence Update: Comparative Effectiveness of Dietary Programs for Reducing Mortality and Cardiovascular Events in Adults with Increased Cardiovascular Disease Risk.

Esmaeilinezhad Z (2025) · Advances in nutrition (Bethesda, Md.)

117.

Efficacy of an avocado-based Mediterranean diet on serum lipids for secondary prevention after ischemic stroke: a randomized phase 2 controlled pilot trial.

Olavarría VV (2025) · Lipids in health and disease

118.

Impact of adherence to the Mediterranean diet on stroke risk.

Ungvari Z (2025) · GeroScience

119.

A High Omega-3, Low Omega-6 Diet Reduces Headache Frequency and Intensity in Persistent Post-Traumatic Headache: A Randomized Trial.

Zamora D (2025) · Journal of neurotrauma · n=60

120.

Omega-3 polyunsaturated fatty acids and nonalcoholic fatty liver disease in adults: A meta-analysis of randomized controlled trials.

Kim SJ (2025) · Clinical nutrition (Edinburgh, Scotland)

121.

Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis.

Amanat S (2025) · Advances in nutrition (Bethesda, Md.)

122.

Flaxseed intervention and reproductive endocrine profiles in patients with polycystic ovary syndrome: an open-labeled randomized controlled clinical trial.

Najdgholami Z (2025) · Frontiers in endocrinology

123.

Can Omega-3 fatty acid supplementation support the clinical management of drug-resistant epilepsy? A meta-analysis of randomized controlled trials.

Meng X (2025) · Seizure

124.

Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis.

Urata M (2025) · Neuropsychopharmacology reports

125.

Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial.

Bischoff-Ferrari HA (2025) · Nature aging · n=777

126.

Obesity and Metabolic Disease Impair the Anabolic Response to Protein Supplementation and Resistance Exercise: A Retrospective Analysis of a Randomized Clinical Trial with Implications for Aging, Sarcopenic Obesity, and Weight Management.

Nilsson MI (2024) · Nutrients

127.

Efficacy and Safety of SmofKabiven® Versus Hospital-Compounded All-in-One Parenteral Nutrition in Chinese Patients Undergoing Gastrointestinal Surgery: A Multicenter, Randomized, Active-Controlled, Phase III Trial.

Wu G (2025) · Nutrition and cancer

128.

The Effect of Dietary Supplements on Male Infertility in Terms of Pregnancy, Live Birth, and Sperm Parameters: A Systematic Review and Meta-Analysis.

Michaelsen MP (2025) · Nutrients

129.

Marine n-3 polyunsaturated fatty acids slow sleep impairment progression by regulating central circadian rhythms in type 2 diabetes.

Zhuang P (2025) · Cell reports. Medicine · n=27,549

130.

Effects of Omega-3 Fatty Acids on Oral Mucositis Induced by Anticancer Therapy: A Meta-Analysis.

Tang X (2025) · Nutrition and cancer · n=337

131.

Daily egg intake may reduce sensitisation to common allergenic foods among six- to nine-month-old south African infants: A randomized controlled trial.

Nakiranda R (2025) · Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

132.

Effects of aspirin and omega-3 fatty acids on age-related macular degeneration in ASCEND-Eye: a randomised placebo-controlled trial in a population with diabetes.

Sammons E (2025) · BMJ open

133.

The Role of Omega-3 Polyunsaturated Fatty Acids in Patients with Metabolic Syndrome and Endothelial Dysfunction.

Dzupina A (2024) · Medicina (Kaunas, Lithuania) · n=80

134.

Boosting Recovery: Omega-3 and Whey Protein Enhance Strength and Ease Muscle Soreness in Female Futsal Players.

Ahmadi M (2024) · Nutrients

135.

High dose arachidonic and docosahexaenoic acid in very preterm infants and neurodevelopment at 2 years - A double-blind randomized controlled trial.

Gunnarsdottir G (2025) · Clinical nutrition (Edinburgh, Scotland)

136.

A Web-Based Lifestyle-Related Course for People Living With Multiple Sclerosis: Quantitative Evaluation of Course Completion, Satisfaction, and Lifestyle Changes Among Participants Enrolled in a Randomized Controlled Trial.

Yu M (2025) · JMIR human factors

137.

Influences of enteral nutritional enriched with n-3 polyunsaturated fatty acids on postoperative wound infection following gastrointestinal surgery: A meta-analysis.

Zhang M (2025) · Journal of tissue viability

138.

Effect of enteral supplementation of DHA with or without ARA in preterm infants: a meta-analysis.

Dang D (2025) · Archives of disease in childhood. Fetal and neonatal edition

139.

Meta-regression of the relationship between dietary 18C n-3 concentration and enrichment of n-3 fatty acids in liver and breast muscle of broiler chickens.

Ali U (2025) · Lipids

140.

Omega and heart rate variability in overweight and obese schoolchildren.

Ibrahim HAA (2025) · Pediatric research

141.

Pharmacological preventions and treatments for pericardial complications after open heart surgeries.

Malektojari A (2025) · Heart (British Cardiac Society)

142.

An Adapted Cardioprotective Diet with or Without Phytosterol and/or Krill Oil Supplementation in Familial Hypercholesterolemia: Results of a Pilot Randomized Clinical Trial.

de Abreu-Silva EO (2025) · Nutrients · n=58

143.

Major depressive disorder in children and adolescents is associated with reduced hair cortisol and anandamide (AEA): cross-sectional and longitudinal evidence from a large randomized clinical trial.

Walther A (2025) · Translational psychiatry

144.

Exploratory outcomes of the DHA WIN randomized controlled trial: Supplementing women with docosahexaenoic acid did not reduce the impact of neoadjuvant breast cancer chemotherapy on quality of life or exercise behaviour.

Douglas CM (2025) · PloS one

145.

Parenteral Nutrition Containing Fish Oil for Hospitalized Non-Intensive Care Unit (ICU) Patients: A Systematic Review, Meta-Analysis, and Cost-Effectiveness Analysis.

Pradelli L (2025) · Nutrients

146.

The effects of concurrent alpha-linolenic acid, L-carnitine supplementation on clinical symptoms, mental health, and quality of life in women with migraine: a randomized, triple-blind, placebo-controlled trial.

Golpour-Hamedani S (2025) · Nutrition journal

147.

Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial.

Aggarwal R (2025) · Journal of the American Heart Association

148.

The combined effects of omega-3 polyunsaturated fatty acid supplementation and exercise training on body composition and cardiometabolic health in adults: A systematic review and meta-analysis.

Khalafi M (2025) · Clinical nutrition ESPEN

149.

Inverse association between eicosapentaenoic acid and incident colorectal cancer: a dose-response meta-analysis of twenty-six independent prospective cohorts.

Chen W (2025) · European journal of nutrition

150.

Neuroprotective nutrients in pregnancy and infant brain function.

Christifano DN (2025) · Clinical nutrition ESPEN · n=241

151.

Adding Lemon and n-3 PUFA-Rich Oil to Tomato Juice Preload to a Carbohydrate Meal Ameliorates Early Glycemic and Insulin Responses in Young Healthy Women: A Randomized Crossover Trial.

Higuchi Y (2025) · Journal of nutritional science and vitaminology

152.

High-dose docosahexaenoic acid for bronchopulmonary dysplasia severity in very preterm infants: a collaborative individual participant data meta-analysis.

Marc I (2025) · The American journal of clinical nutrition

153.

Can prenatal conditions impact the effect of omega-3 on bronchopulmonary dysplasia in very preterm infants? A secondary analysis of a randomized controlled trial.

Rais H (2025) · European journal of pediatrics

154.

Preventing psychosis in people at clinical high risk: an updated meta-analysis by the World Psychiatric Association Preventive Psychiatry section.

Minichino A (2025) · Molecular psychiatry

155.

Association between inflammatory biomarkers and the cognitive response to a multidomain intervention: secondary longitudinal analyses from the MAPT study.

Gonzalez-Bautista E (2025) · GeroScience · n=1,527

156.

Safety and efficacy of docosahexaenoic acid supplementation during neoadjuvant breast cancer therapy: Findings from the phase II, double-blind, randomized controlled DHA-WIN trial.

Munhoz J (2025) · International journal of cancer

157.

Docosahexaenoic acid (DHA) supplementation attenuates changes in the concentration, phenotype, and response of immune peripheral blood cells in breast cancer patients undergoing neoadjuvant therapy. Secondary findings from the DHA-WIN trial.

Munhoz J (2025) · Breast cancer research : BCR

158.

Effects of Different Proportions of DHA and ARA on Cognitive Development in Infants: A Meta-Analysis.

Tian A (2025) · Nutrients

159.

Anti-inflammatory interventions for the treatment and prevention of depression among older adults: a systematic review and meta-analysis.

Gong H (2025) · Translational psychiatry

160.

Inflammatory markers after supplementation with marine n-3 or plant n-6 PUFAs: A randomized double-blind crossover study.

Grytten E (2025) · Journal of lipid research

161.

Omega-3 and aspirin in the nonsurgical treatment of grade C periodontitis: A randomized clinical trial.

Araujo CF (2025) · Journal of periodontology

162.

Impact of Fatty Acid Supplementation on Migraine Outcomes: A Systematic Review and Meta-analysis.

García-Pérez-de-Sevilla G (2025) · Nutrition reviews

163.

[Docosahexaenoic acid benefits on growth and body composition of septic neonates. Randomized trial].

Bernabe-García M (2025) · Revista medica del Instituto Mexicano del Seguro Social

164.

Analysis of factors predisposing dairy Assaf ewes to marine lipid-induced milk fat depression.

Della Badia A (2025) · Animal : an international journal of animal bioscience

165.

Randomized dose-response trial of n-3 fatty acids in hormone receptor negative breast cancer survivors - impact on breast adipose oxylipin and DNA methylation patterns.

Frankhouser DE (2025) · The American journal of clinical nutrition

166.

Effects of Omega-3 PUFAs on lipid profiles and antioxidant response in depressed adolescents: A metabolomic and lipidomic study.

Wang J (2025) · Redox biology

167.

Reduction of cardiovascular risk factors by the diet - Evaluation of the MoKaRi concept by a parallel-designed randomized study.

Dawczynski C (2025) · Lipids in health and disease

168.

Vitamin D Supplementation, Chronic Obstructive Lung Disease and Asthma Exacerbations, and Lung Function Decline.

Gold DR (2025) · The Journal of nutrition

169.

The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis.

Tseng PT (2025) · Advances in nutrition (Bethesda, Md.) · n=9,075

170.

Supplementation of Omega-3 Increases Serum Levels of Brain-Derived Neurotrophic Factor and Decreases Depression Status in Patients With Bipolar Disorder: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Gholipour D (2025) · Journal of human nutrition and dietetics : the official journal of the British Dietetic Association

171.

Comparison of the effects of pemafibrate and omega-3 fatty acid ethyl on fatty liver index in patients with dyslipidemia treated with statin: a sub-analysis from the PROUD48 study.

Takeda Y (2025) · Frontiers in endocrinology

172.

Calanus Oil and Lifestyle Interventions Improve Glucose Homeostasis in Obese Subjects with Insulin Resistance.

Kerlikowsky F (2025) · Marine drugs · n=266

173.

Effectiveness of plant and animal-based interventions in preventing and reducing pressure injuries: A systematic review and meta-analysis.

Özkan E (2025) · Journal of tissue viability

174.

Exploration of the optimized portrait of omega-3 polyunsaturated fatty acids in treating depression: A meta-analysis of randomized-controlled trials.

Kong L (2025) · Journal of affective disorders

175.

Effects of seal oil supplementation on lipid profile biomarkers: A systematic review and meta-analysis of randomized controlled trials.

Gallo Ruelas M (2025) · Prostaglandins, leukotrienes, and essential fatty acids

176.

The role of the Mediterranean diet in reducing the risk of cognitive impairement, dementia, and Alzheimer's disease: a meta-analysis.

Fekete M (2025) · GeroScience

177.

Nut consumption, linoleic and α-linolenic acid intakes, and genetics: how fatty acid desaturase 1 impacts plasma fatty acids and type 2 diabetes risk in EPIC-InterAct and PREDIMED studies.

Jäger S (2025) · BMC medicine

178.

Polygenic Risk and Nutrient Intake Interactions on Obesity Outcomes: A Systematic Review and Meta-Analysis of Observational Studies.

Masip G (2025) · Obesity reviews : an official journal of the International Association for the Study of Obesity

179.

Effect of omega-3 polyunsaturated fatty acid on endometriosis.

Liu E (2025) · Clinics (Sao Paulo, Brazil)

180.

Docosahexaenoic Acid Supplementation During Pregnancy and Lactation and Infant Morbidity: Findings from DHANI Trial.

Khandelwal S (2025) · Indian pediatrics

181.

Supplementation of medium-chain triglycerides combined with docosahexaenoic acid improves cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial.

Duan H (2025) · Journal of affective disorders

182.

A Multicenter, Randomized, Clinical Trial Assessing the Effect of rTG-Omega 3 Supplementation on Meibomian Gland Dysfunction Patients after Cataract Surgery rTG-Omega 3 for Meibomian Gland Dysfunction.

Hong S (2025) · Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · n=107

183.

The impact of Omega-3 supplementation on arrhythmia reduction in acute coronary syndrome patients: a randomized clinical trial.

Hemmati R (2025) · Journal of complementary & integrative medicine

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