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Iron

Also known as: ferrous bisglycinate, iron bisglycinate, ferrous sulfate

SStrong Evidence54 studies referenced

Common dosage

18-27mg daily (if deficient)

Category

mineral

Description

Essential mineral for oxygen transport and energy production. Only supplement if deficient — excess iron is harmful.

Safety & interactions

Test ferritin before supplementing. Take with vitamin C. Avoid with calcium, zinc, tea, coffee.
Check all interactions →

Studies on Iron (54)

1.

Iron deficiency and cognitive functions

Jáuregui-Lobera I (2014) · Neuropsychiatr Dis Treat

ReviewPubMed
2.

Essential Trace Elements and Their Impact on Immune Response and Disease Severity in Malaria Infection: A Systematic Review.

Hanifian H (2026) · Parasite immunology

3.

Efficacy of daily versus alternate day oral iron supplementation for management of anaemia among general population: a systematic review and meta-analysis.

Dhanvijay AD (2025) · BMC pharmacology & toxicology

4.

Efficacy and safety of intravenous ferric carboxymaltose in the treatment of Restless Legs Syndrome: a systematic review and meta-analysis.

Khan A (2024) · Frontiers in neurology

5.

Anemia in pregnancy: a systematic review and meta-analysis of prevalence, determinants, and health impacts in Egypt.

Azzam A (2025) · BMC pregnancy and childbirth

6.

Effect of Interventions on Iron-Deficiency Anemia Among School-Going Children in India: A Systematic Review and Network Meta-Analysis.

Felix F (2025) · Journal of research in health sciences

7.

Intermittent versus daily oral iron folic acid supplementation and pregnancy outcome in low- and middle-income countries: a systematic review and meta-analysis of experimental studies.

Chillo SL (2025) · Reproductive health

8.

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.

Qi YP (2026) · The Cochrane database of systematic reviews

9.

Impact of Vegan and Vegetarian Diets on Neurological Health: A Critical Review.

Clemente-Suárez VJ (2025) · Nutrients

10.

Modifiable risk factors for anemia in pregnancy: an umbrella review of systematic reviews and meta-analyses.

Dagne WK (2025) · BMC pregnancy and childbirth

11.

Evidence-Based Supplementation Strategies for Wrestlers: A Systematic Review.

Coutiño Díaz M (2025) · Current nutrition reports

12.

Preoperative iron supplementation in non-anemic patients undergoing major surgery: a systematic review and meta-analysis.

Toledo FV (2025) · Brazilian journal of anesthesiology (Elsevier)

13.

The effect of prenatal balanced energy and protein supplementation on small vulnerable newborn types in low- and middle-income countries: A systematic review and meta-analysis of individual participant data.

Wang D (2026) · PLoS medicine

14.

Are there prophylactic effects of vitamin D among healthier adult patients? A systematic review of randomized controlled trials.

Goswami C (2025) · BMC nutrition

15.

Effect of iron supplements on cognitive development in children: an umbrella review.

Caballero-Apaza LM (2026) · Frontiers in nutrition

16.

Effect of prenatal multiple micronutrient supplementation compared with iron and folic acid supplementation on size at birth and subsequent growth through 24 mo of age: a systematic review and meta-analysis.

Gomes F (2025) · The American journal of clinical nutrition

17.

Effects of Nutrition-Specific Interventions to Prevent and Control Nutrition-Related Anemia in Infants, Children, and Adolescents: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.

Ren T (2025) · Journal of the Academy of Nutrition and Dietetics

18.

Contribution of Maternal Adherence to the Effect of Multiple Micronutrient Supplementation During Pregnancy: A Systematic Review and Individual Participant Data Meta-analysis.

Smith ER (2025) · Advances in nutrition (Bethesda, Md.)

19.

Advances in Supportive Therapy for Patients With Thalassemia: A Systematic Review.

Septian RB (2026) · Biological research for nursing

20.

Efficacy and safety of intravenous iron supplementation for perioperative iron deficiency anemia: a systematic review and network meta-analysis of randomized controlled trials.

Xue Q (2026) · Journal of clinical anesthesia

21.

Impact of Helicobacter pylori infection on iron deficiency anemia in children: a systematic review and meta-analysis with early intervention implications.

Wang Z (2025) · Frontiers in microbiology

22.

High-dose intravenous iron significantly reduces the risk of red blood cell transfusion and improves postoperative hemoglobin levels after cardiac surgery: A systematic review of randomized controlled trials.

Wang L (2025) · PloS one

23.

Optimal dose and duration of iron supplementation for treating iron deficiency anaemia in children and adolescents: A systematic review and meta-analysis.

Rehman T (2025) · PloS one

24.

Systematic review on supplementation, fortification, and food-based interventions for preventing iron deficiency anemia in low- and middle-income countries.

Helmyati S (2025) · Asia Pacific journal of clinical nutrition

25.

Clinical characteristics, management, and outcomes of cadmium poisoning: a systematic review of case reports and case series.

Shao Z (2025) · Frontiers in public health

26.

Prevalence and associated factors of anemia among newborns in Ethiopia: a systematic review and meta-analysis.

Mekonen H (2025) · Journal of pediatric nursing

27.

Preoperative intravenous versus oral iron supplementation for elective surgery: evidence based on 12 randomized trials.

Yue L (2025) · Postgraduate medicine

28.

The effect of intravenous iron supplementation compared to oral iron supplementation during pregnancy on neonatal outcomes-a systematic review of randomized controlled trials.

Kuitunen I (2025) · European journal of pediatrics

29.

Effectiveness of various interventions for patients with preoperative anemia undergoing cardiac surgery: a Bayesian network meta-analysis and systematic review.

Chen Y (2026) · International journal of surgery (London, England)

30.

Effectiveness of mHealth-Based Nutritional Interventions on Iron Status of Pregnant Women: Systematic Review of Randomized Controlled Trials.

Belay SA (2026) · JMIR mHealth and uHealth

31.

Prevalence and correlates of anemia following Roux-en-Y gastric bypass: a systematic review and meta-analysis.

Gao Z (2025) · International journal of surgery (London, England)

32.

Alpha-lipoic acid on intermediate disease markers in overweight or obese adults: a systematic review and meta-analysis.

Luo Y (2025) · BMJ open

33.

The effects of prenatal multiple micronutrient supplementation and small-quantity lipid-based nutrient supplementation on small vulnerable newborn types in low-income and middle-income countries: a meta-analysis of individual participant data.

Wang D (2025) · The Lancet. Global health

34.

The efficacy of dietary supplements on health status and performance of football players: a systematic review.

Allahyari P (2025) · Journal of basic and clinical physiology and pharmacology

35.

Long-Term Effects of Multiple-Micronutrient Supplementation During Pregnancy, Lactation, and Early Childhood on the Cognitive Development of Children Aged 4-14 Years: A Systematic Review of Randomized Controlled Trials.

William A (2025) · Nutrients

36.

Effect of iron supplementation in healthy exclusively breastfed infants: a systematic review and meta-analysis.

Tian K (2025) · Frontiers in pediatrics

37.

Guidelines on Placenta Accreta Spectrum Disorders: A Systematic Review.

Bonanni G (2025) · JAMA network open

38.

The association between iron supplementation during pregnancy and the risk of childhood leukemia: a meta-analysis of case-control studies.

Dabir M (2025) · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

39.

Effect of probiotic and prebiotics supplementation on hemoglobin levels and iron absorption among women of reproductive age and children: a systematic review and meta-analysis.

Apte A (2025) · BMC nutrition

40.

Psychiatric and cognitive outcomes of iron supplementation in non-anemic children, adolescents, and menstruating adults: A meta-analysis and systematic review.

Fiani D (2025) · Neuroscience and biobehavioral reviews · n=1,408

41.

Comparative efficacy of different dietary interventions for cardiopulmonary fitness at high altitude: a systematic review and network meta-analysis.

Wang B (2025) · Frontiers in nutrition

42.

The effects of antenatal interventions on gestational weight gain in low and middle-income countries: a systematic review.

Aggrey PA (2026) · BMJ global health

43.

The benefits and harms of oral iron supplementation in non-anaemic pregnant women: a systematic review and meta-analysis.

Watt A (2025) · Family practice

44.

Impact of TMPRSS6 Genetic Variants on Maternal Iron Status in Pregnancy: A Systematic Review.

Fauzan R (2025) · Birth defects research

45.

Oral iron supplements for children in malaria-endemic areas.

Itzkovich M (2026) · The Cochrane database of systematic reviews

46.

Maternal and newborn health inequality among Syrian refugees in Turkey: a systematic review and meta-analysis.

Hakimi S (2025) · International journal for equity in health

47.

Is the Juice Worth the Squeeze? Vitamin C Supplementation in Hemodialysis Patients: A Systematic Review.

Sikorska-Wiśniewska M (2026) · Nutrients

48.

Indications for the evaluation and supplementation of hypophosphatemia: an umbrella systematic review of reviews and guidelines.

Netzer S (2025) · BMC medicine

49.

Micronutrient and protein-energy supplementation enhance vaccine responses in undernourished children: Evidence from a systematic review.

Ngoie Mwamba G (2025) · F1000Research

50.

Vegan diet and nutritional status in infants, children and adolescents: A position paper based on a systematic search by the ESPGHAN Nutrition Committee.

Verduci E (2025) · Journal of pediatric gastroenterology and nutrition

51.

Arthrospira platensis and Chlorella vulgaris Consumption on Iron Status: A Systematic Review of In Vivo Studies.

Lacurezeanu A (2025) · Molecular nutrition & food research

52.

Intravenous Iron in Heart Failure Patients With Iron Deficiency: A Meta-Analysis of Randomized Controlled Trials.

Liu Y (2025) · Journal of evidence-based medicine

53.

Acceptability of Antenatal Multiple Micronutrient Supplementation (MMS) Compared to Iron and Folic Acid (IFA) Supplementation in Pregnant Individuals: A Narrative Review.

Kissell MC (2025) · Nutrients

54.

Alpha Lipoic Acid Supplementation and Iron Homeostasis: A Comprehensive Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials.

Sharifi-Zahabi E (2024) · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition

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