Latest evidence update: 2026-12-30
One-off plan, anchored to the night you're going out. We'll generate a calendar file you can drop into Google Calendar, Apple Calendar, or Outlook.
5 hours BEFORE drinking. Wiese 2004 (Archives of Internal Medicine, n=55 RCT) — risk of severe hangover halved; nausea, dry mouth, anorexia significantly reduced; CRP 40% lower. Strongest single-ingredient hangover RCT we have.
03:00 PM
May 21
5h before
NAC peak absorption is 45-60 minutes. Take at T-60 so glutathione availability is at peak when alcohol metabolism starts, not still ramping.
07:00 PM
May 21
1h before
With NAC at T-60. Mechanism: aldehyde dehydrogenase upregulation accelerates acetaldehyde clearance. Strong animal data, single 2024 human RCT positive. Label as plausible mechanism with emerging human signal.
07:00 PM
May 21
1h before
during drinking
10:00 PM
May 21
2h after
before bed
12:00 AM
May 22
4h after
Before bed. Alcohol fragments REM in the second half of sleep — magnesium glycinate's relevant action is supporting sleep architecture during overnight alcohol metabolism, not the morning after.
12:00 AM
May 22
4h after
morning after
08:00 AM
May 22
12h after
Morning after, with B-complex or standalone. Alcohol inhibits intestinal thiamine absorption by up to 50%; deficiency drives the fatigue/confusion/weakness pattern of hangover. Cleaner mechanistic case than generic B-complex.
08:00 AM
May 22
12h after
morning after
09:00 AM
May 22
13h after
Opens an .ics file — your calendar app handles the rest. Nothing stored on our side.
ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.