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Not recommended

Human studies show no meaningful benefit, potential harm, or the risks outweigh any possible upside. Better alternatives exist.

Prickly Pear Extract (Opuntia ficus indica)

Also known as: opuntia ficus indica, opuntia, nopal, prickly pear cactus extract

Confidence

research strength

EInsufficient evidence00 studies referenced

Effect by outcome

how big the change is

No quantified outcomes yet. Once we have studies with measurable endpoints, you will see per-outcome magnitude here.

Common dosage

1600mg standardized extract, 5 hours before drinking

Description

Anti-inflammatory cactus extract. Single landmark RCT (Wiese et al., Tulane/UCSF, n=55, Archives of Internal Medicine 2004): 1600mg standardized extract 5 hours before drinking halved the risk of severe hangover; significantly reduced nausea, dry mouth, anorexia. CRP 40% lower. Strongest single-ingredient human RCT in the hangover literature.

Safety & interactions

Generally well-tolerated. May cause mild GI effects. Possible additive blood glucose lowering with antidiabetic medications.

Check interactions with other supplements→

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Recommended: 1600mg standardized extract, 5 hours before drinking

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Questions about Prickly Pear Extract (Opuntia ficus indica)

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ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.