longevity · Outcome
Years of healthy, disease-free life ahead.
How to measure:
Three levers, one stack. Each works through a different mechanism. They compound.
10% mortality reduction
2000-5000 IU daily
Effect size
Corpus
38 papers
range 7–45 · n=5 quantitative claims
“Vitamin D3 supplementation (2000 IU/day) reduced mortality risk in patients with digestive tract cancer in the highest quintile (Q5) of serum PD-L1, with a hazard ratio of 0.34 (95% CI: 0.12-0.92).”
Meaningful
45-120 min, 3-4x per week
Effect size
Corpus
5 papers
0 small · 7 moderate · 2 large · 1 unclear
“Among males with sedentary work, high compared to sedentary leisure-time physical activity was associated with lower all-cause mortality risk (HR=0.77, 95% CI: 0.70-0.85).”
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Every pick has two signals. They answer different questions and we never bundle them into one number.
Effect size
How big is the change on healthspan, in the units that matter for this outcome.
Confidence
How sure are we the effect is real for healthspan, given the studies we have.
For every pick, the “papers” number is how many studies we've cataloged that test this entity for healthspan. “Favorable” means the study reported the direction you want.
The tier badge (S, A, B…) on the entity itself is its overall research confidence across all outcomes. It's the same letter wherever you see this entity on the site, not specific to healthspan.
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