Also known as: quit smoking, tobacco cessation, stop smoking
Latest evidence update: 2026-04-01
Strongest in Sample size (95). Held back by Study quality (73).
Solid mix of RCTs with some methodological gaps.
Confirmed across many independent studies with significant findings.
Tens of thousands of participants pooled across studies.
Studies agree on direction of effect.
Healthy mix of recent and established research.
Areas where research points to a consistent direction of effect. The strength of evidence is graded; the size of the effect is not quantified.
Quitting smoking is the single highest-yield lifestyle change for smokers. Current smoking raises CVD mortality 2.3-fold and cancer mortality 3.4-fold. After quitting, most excess cardiovascular risk is eliminated within a decade.
ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.
Acceptance and commitment therapy significantly improved short-term cessation rates compared with behavioral support.
Nicotine electronic cigarettes result in increased quit rates compared to nicotine replacement therapy (NRT).
Study 1 (n=423) showed L-cysteine lozenge was more effective than placebo in per-protocol analysis with improved success rates.
Smoking cessation is associated with marginal improvement in forced expiratory volume in one second (FEV1) in patients with chronic respiratory diseases.
The pooled post-intervention smoking abstinence rate across follow-up periods was 18.8%.