Folate

Also known as: methylfolate, 5-MTHF, folic acid, vitamin B9

AAdequate Evidence73229 studies referenced

Latest evidence update: 2024-12-28

Mental health & wellbeing Cardiovascular health

Common dosage

400-800mcg daily

Description

Essential for DNA synthesis and methylation. Methylfolate is the active form — important for those with MTHFR variants.

Safety & interactions

Methylfolate preferred over folic acid, especially with MTHFR mutations.

Check interactions with other supplements→

Expected outcomes

Outcome estimates are derived from published research and represent population-level associations, not guaranteed individual results. Consult a healthcare professional before making decisions based on these estimates.

Supports these goalsvia evidence graph

Metabolic HealthC1 study row
metabolic flexibility
CognitionC1 study row
cognitive clarity

Goals matched from this supplement's aggregated claim evidence using the same logic that drives the quiz picker.

What the research shows

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People with Alzheimer's disease have lower folate levels compared to those without the disease

moderate evidence1 study:Journal of human nutrition and dietetics : the official journal of the British Dietetic Association (2025)

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Eating salt fortified with multiple nutrients can help increase folate levels in the blood

emerging evidence1 study:Advances in nutrition (Bethesda, Md.) (2026)

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Order Folate

Recommended: 400-800mcg daily

Protocols featuring Folate

Iron & Energy RecoveryAAdequate Evidence

Fertility & Prenatal OptimizationAAdequate Evidence

Questions about Folate

Who has been studied for Folate?

Are there known drug interactions with Folate?

Who should avoid Folate based on the safety notes?

Referenced studies (229)

ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.