Also known as: ascorbic acid, sodium ascorbate
Latest evidence update: 2026-04-01
Strongest in Sample size (95). Held back by Recency (24).
Solid mix of RCTs with some methodological gaps.
Confirmed across many independent studies with significant findings.
Tens of thousands of participants pooled across studies.
Mostly aligned, with some divergence.
Mostly pre-2020 research; updates may be needed.
Effect-size tagged on 391 of 400 claims for this supplement. Our research updates daily; remaining claims are pending re-processing.
Areas where research points to a consistent direction of effect. The strength of evidence is graded; the size of the effect is not quantified.
Recommended: 500-1000mg daily
ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.
May help reduce cholesterol and triglyceride levels in people with diabetes or on dialysis
Could slightly lower blood pressure, with a modest reduction of about 3-4 mmHg in some people
May help reduce insulin resistance in people with type 2 diabetes through its antioxidant properties
Could help reduce symptoms of restless legs syndrome and improve iron function in dialysis patients
May reduce muscle damage and speed recovery after intense exercise