Also known as: selenium methionine, selenomethionine
Latest evidence update: 2026-04-10
Strongest in Sample size (95). Held back by Recency (16).
Solid mix of RCTs with some methodological gaps.
Confirmed across many independent studies with significant findings.
Tens of thousands of participants pooled across studies.
Mostly aligned, with some divergence.
Mostly pre-2020 research; updates may be needed.
Effect-size tagged on 397 of 400 claims for this supplement. Our research updates daily; remaining claims are pending re-processing.
Areas where research points to a consistent direction of effect. The strength of evidence is graded; the size of the effect is not quantified.
Recommended: 100-200mcg daily
ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.
May help prevent complications during pregnancy and support healthy birth outcomes by maintaining adequate selenium levels
May improve blood sugar control and fat metabolism in pregnant women with gestational diabetes
Can reduce symptoms of overactive thyroid disease when combined with standard medication, including tremors, mood changes, and heat sensitivity
May allow patients with overactive thyroid disease to use lower doses of medication to achieve disease remission
May provide clinical benefits for people with autoimmune thyroid disease