Also known as: choline bitartrate
Latest evidence update: 2026-09-16
Outcome estimates are derived from published research and represent population-level associations, not guaranteed individual results. Consult a healthcare professional before making decisions based on these estimates.
Recommended: 500mg daily
ProtocolEngine provides general health information based on published research. This is not medical advice. Consult a healthcare professional before starting any supplement or health protocol.
May reduce cancer risk when consumed at adequate dietary levels, with some evidence suggesting up to 40% reduction in overall cancer risk with combined choline and betaine intake
Higher circulating choline levels are associated with increased risk of cardiovascular disease, heart failure, and all-cause mortality
May support healthy pregnancy outcomes and reduce risk of gestational diabetes when maternal choline levels are adequate
Choline naturally increases substantially in breast milk as lactation progresses, from colostrum to mature milk, supporting infant nutrition
May reduce urge urinary incontinence risk in premenopausal women by approximately 21-26% with higher dietary intake