Latest evidence update: 2026-04-15
Strongest in Consistency (80). Held back by Recency (54).
Solid mix of RCTs with some methodological gaps.
Good cross-study replication, some imprecision.
Thousands of participants across the literature.
Studies agree on direction of effect.
Evidence base skews older; field may have moved on.
Areas where research points to a consistent direction of effect. The strength of evidence is graded; the size of the effect is not quantified.
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Honey mouthwash is more efficacious than chlorhexidine mouthwash in preventing intolerable oral mucositis.
Honey mouthwash is superior to placebo in preventing intolerable oral mucositis in cancer patients.
Thyme honey is significantly more effective than 0.1% triamcinolone acetonide in reducing pain and ulcer size in minor recurrent aphthous stomatitis.
Natural products including honey, propolis, chamomile, and Plantago major L. exert anti-inflammatory and antioxidant properties that contribute to preventing and treating oral mucositis.
Honey significantly reduces the incidence of moderate-to-severe oral mucositis (grade ≥2) compared to standard care in cancer patients.