Latest evidence update: 2025-10-22
Strongest in Consistency (85). Held back by Replication (51).
Solid mix of RCTs with some methodological gaps.
Some independent replication, statistical precision uneven.
Thousands of participants across the literature.
Studies agree on direction of effect.
Most studies are recent (last 2-3 years).
No quantified outcomes yet. Once we have studies with measurable endpoints, you will see per-outcome magnitude here.
Dark chocolate/cocoa consumption has no significant effect on thiobarbituric acid reactive substances (TBARS) levels in adults.
Greater anti-inflammatory effects of dark chocolate/cocoa occur at higher flavonoid doses greater than 450 mg/day.
Dark chocolate/cocoa consumption has no significant effect on E-selectin levels in adults.
Dark chocolate/cocoa consumption significantly increases nitric oxide (NO) levels in adults.
Dark chocolate/cocoa consumption has no significant effect on interleukin-6 (IL-6) levels in adults.
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