Latest evidence update: 2026-05-24
Strongest in Study quality (72). Held back by Consistency (44).
Solid mix of RCTs with some methodological gaps.
Good cross-study replication, some imprecision.
Thousands of participants across the literature.
Mixed direction across studies.
Healthy mix of recent and established research.
No quantified outcomes yet. Once we have studies with measurable endpoints, you will see per-outcome magnitude here.
Dark chocolate/cocoa consumption significantly reduces malondialdehyde (MDA) levels, a marker of oxidative stress, in adults.
Dark chocolate/cocoa consumption has no significant effect on thiobarbituric acid reactive substances (TBARS) levels in adults.
Greater anti-inflammatory effects of dark chocolate/cocoa occur at higher flavonoid doses greater than 450 mg/day.
Dark chocolate/cocoa consumption has no significant effect on E-selectin levels in adults.
Dark chocolate/cocoa consumption significantly increases nitric oxide (NO) levels in adults.
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