Latest evidence update: 2026-05-21
Greater anti-inflammatory effects of dark chocolate/cocoa occur at higher flavonoid doses greater than 450 mg/day.
Dark chocolate/cocoa consumption has no significant effect on thiobarbituric acid reactive substances (TBARS) levels in adults.
Dark chocolate/cocoa consumption has no significant effect on E-selectin levels in adults.
Dark chocolate/cocoa consumption significantly increases nitric oxide (NO) levels in adults.
Anti-inflammatory effects of dark chocolate/cocoa are greater for shorter intervention durations (≤4 weeks) in non-healthy participants.
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